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8-Methyl-1,2,3,4-tetrahydroquinoline manufacturers
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| | 8-Methyl-1,2,3,4-tetrahydroquinoline Basic information |
| Product Name: | 8-Methyl-1,2,3,4-tetrahydroquinoline | | Synonyms: | 8-METHYL-1,2,3,4-TETRAHYDROQUINOLINE;AKOS B016010;AKOS BB-9798;ART-CHEM-BB B016010;8-Methyl-1,2,3,4-tetrahydroquinoline 98%;Quinoline, 1,2,3,4-tetrahydro-8-methyl- | | CAS: | 52601-70-4 | | MF: | C10H13N | | MW: | 147.22 | | EINECS: | | | Product Categories: | | | Mol File: | 52601-70-4.mol |  |
| | 8-Methyl-1,2,3,4-tetrahydroquinoline Chemical Properties |
| Boiling point | 255 °C | | density | 0.990±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | form | liquid | | pka | 5.01±0.20(Predicted) | | color | Light brown | | CAS DataBase Reference | 52601-70-4 |
| | 8-Methyl-1,2,3,4-tetrahydroquinoline Usage And Synthesis |
| Uses | 8-Methyl-1,2,3,4-tetrahydroquinoline is a useful reagent for template-directed meta-C-H activation. | | Definition | ChEBI: 8-Methyl-1,2,3,4-tetrahydroquinoline is a member of quinolines. | | Synthesis Reference(s) | The Journal of Organic Chemistry, 25, p. 463, 1960 DOI: 10.1021/jo01073a611 | | Synthesis | The general procedure for the synthesis of 8-methyl-1,2,3,4-tetrahydroquinoline from 8-methylquinoline is as follows: unlike the Suzuki-Miyaura coupling reaction, the Pd-pol catalyst exhibits truly non-homogeneous catalytic properties for the reduction of nitroaromatics in the aqueous phase (see Table 2) [46]. In addition, the catalyst can be used for the selective hydrogenation of quinoline derivatives in aqueous-phase media at a pressure of 10 bar H2 at a reaction temperature of 80 °C (cf. Table 3) [47] or at 60 °C with NaBH4 as a hydrogen source (cf. Table 4) [48]. | | References | [1] Molecules, 2015, vol. 20, # 10, p. 18661 - 18684
[2] Advanced Synthesis and Catalysis, 2017, vol. 359, # 6, p. 933 - 940
[3] Chemical Communications, 2013, vol. 49, # 63, p. 7052 - 7054
[4] Advanced Synthesis and Catalysis, 2016, vol. 358, # 19, p. 3039 - 3045
[5] Patent: CN106831565, 2017, A. Location in patent: Paragraph 0079; 0080; 0081; 0082 |
| | 8-Methyl-1,2,3,4-tetrahydroquinoline Preparation Products And Raw materials |
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