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| | 4-Chloro-6,7-difluoroquinazoline Basic information |
| | 4-Chloro-6,7-difluoroquinazoline Chemical Properties |
| Boiling point | 290.9±35.0 °C(Predicted) | | density | 1.538±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | -0.04±0.70(Predicted) | | Appearance | White to light yellow Solid |
| | 4-Chloro-6,7-difluoroquinazoline Usage And Synthesis |
| Synthesis | Example 4A Step 2: 6,7-difluoro-4-hydroxyquinazoline (910 mg, 5 mmol) was added to trichlorophos (15 mL) followed by triethylamine (700 μL, 5 mmol). The reaction mixture was heated to reflux at 100 °C for 4 h. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The resulting solid was ground with ethyl acetate (2 × 100 mL), and the combined organic phases were rapidly filtered through a silica gel column to afford 4-chloro-6,7-difluoroquinazoline (870 mg, 4.35 mmol, 87% yield). m/z 201 ([M + H]+) by LC-MS (ESI). | | References | [1] Patent: WO2009/117080, 2009, A1. Location in patent: Page/Page column 165
[2] Patent: US2006/281772, 2006, A1. Location in patent: Page/Page column 131 |
| | 4-Chloro-6,7-difluoroquinazoline Preparation Products And Raw materials |
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