benzo[d]oxazole-6-carboxylic acid

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benzo[d]oxazole-6-carboxylic acid manufacturers
benzo[d]oxazole-6-carboxylic acid Basic information
Product Name:benzo[d]oxazole-6-carboxylic acid
Synonyms:benzo[d]oxazole-6-carboxylic acid;6-Benzoxazolecarboxylic acid;Benzoxazole-6-carboxylic Acid;1,3-Benzoxazole-6-carboxylic acid 97%;SB9;Serpin B9-IN-1;1,3-Benzoxazole-6-carboxylic acid, 10 mM in DMSO;1,3-Benzoxazole-6-carboxylic acid
CAS:154235-77-5
MF:C8H5NO3
MW:163.13
EINECS:
Product Categories:
Mol File:154235-77-5.mol
benzo[d]oxazole-6-carboxylic acid Structure
benzo[d]oxazole-6-carboxylic acid Chemical Properties
Melting point 280-290 °C (sublm)(Press: 16 Torr)
Boiling point 350.1±15.0 °C(Predicted)
density 1.455±0.06 g/cm3(Predicted)
storage temp. 2-8°C
form Solid
pka3.60±0.30(Predicted)
color Light brown to brown
Safety Information
HS Code 2934999090
MSDS Information
benzo[d]oxazole-6-carboxylic acid Usage And Synthesis
Uses6-Benzoxazolecarboxylic Acid is a reactant used in the design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as α7 nicotinic acetylcholine receptor agonists.
in vivo

Serpin B9-IN-1 (BTCA) inhibits bone metastasis (BM) in multiple tumor metastasis models. Serpin B9-IN-1 (50 mg/kg/d; ip; 14 d) effectively reduced the survival rate and metastasis proportion of metastatic cancer cells in the mouse bone metastasis model with LLC1-BM3 injected into the tail artery (CA)[1].
Serpin B9-IN-1 (300 μg/d; ip; 14 d) effectively delayed the average time to bone metastasis (BM) in the LLC1-BM3 cell group[1].

Animal Model:LLC1-BM3 Bone Metastatic Mouse Model by CA injections[1]
Dosage:50 mg/kg
Administration:ip; followed after cancer cell injection, injection daily for 14 days
Result:Reduced the survival rate and metastasis proportion of metastatic cancer cells
Animal Model:LLC1-BM3-sr-ctrl Model in Mouse[1]
Dosage:300 μg
Administration:ip; once daily for 14 days
Result:Delayed the mean time to occurrence of bone metastasis (BM), and lowered the burden of BM in LLC1-BM3-shSB9 cells group.
benzo[d]oxazole-6-carboxylic acid Preparation Products And Raw materials
Raw materials4-Amino-3-hydroxybenzoic acid-->Trimethoxymethane
Tag:benzo[d]oxazole-6-carboxylic acid(154235-77-5) Related Product Information
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