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| | Tat-NTS Peptide (trifluoroacetate salt) Basic information |
| | Tat-NTS Peptide (trifluoroacetate salt) Chemical Properties |
| solubility | Water: Soluble |
| | Tat-NTS Peptide (trifluoroacetate salt) Usage And Synthesis |
| Description | Tat-NTS peptide is a cell-penetrating peptide composed of the HIV-1 Tat protein transduction domain linked to a 10-amino acid peptide corresponding to residues 228-237 of the repeat III domain of annexin A1, which functions as a nuclear translocation signal (NTS).1 It blocks the protein-protein interaction between annexin A1 and importin β, preventing nuclear translocation of annexin A1 in primary mouse hippocampal neurons.1 Tat-NTS inhibits glucose-oxygen deprivation and reperfusion-induced apoptosis in primary mouse hippocampal neurons. In vivo, Tat-NTS (10 mg/kg) reduces infarct size and neuronal apoptosis, as well as decreases the time to reach the platform in the Morris water maze test in a mouse model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).WARNING This product is not for human or veterinary use. | | References | [1] XING LI. A novel cell-penetrating peptide protects against neuron apoptosis after cerebral ischemia by inhibiting the nuclear translocation of annexin A1[J]. Cell Death and Differentiation, 2018, 26 2: 260-275. DOI: 10.1038/s41418-018-0116-5 |
| | Tat-NTS Peptide (trifluoroacetate salt) Preparation Products And Raw materials |
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