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Ethyl 2-methylthiazole-4-carboxylate

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Products Intro: Product Name:ETHYL 2-METHYLTHIAZOLE-4-CARBOXYLATE
CAS:6436-59-5
Purity:>=95% Package:10 g，50 g，500 g Remarks:SD51038
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Products Intro: Product Name:Ethyl 2-methyl-1,3-thiazole-4-carboxylate
CAS:6436-59-5
Purity:98% (Min,GC) Package:100g;1kg;5kg,10kg,25kg,50kg
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Products Intro: Product Name:ethyl 2-methylthiazole-4-carboxylate
CAS:6436-59-5
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
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Products Intro: Product Name:ETHYL 2-METHYLTHIAZOLE-4-CARBOXYLATE
CAS:6436-59-5
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Ethyl 2-methylthiazole-4-carboxylate manufacturers
Ethyl 2-methylthiazole-4-carboxylate Basic information
Product Name: Ethyl 2-methylthiazole-4-carboxylate
Synonyms:BUTTPARK 29\06-83;ETHYL 2-METHYLTHIAZOL-4-CARBOXYLATE;ETHYL 2-METHYL-1,3-THIAZOLE-4-CARBOXYLATE;Ethyl 2-methyl-1,3-thiazole-4-carboxylate ,98%;ETHYL 2-METHYLTHIAZO;4-Thiazolecarboxylicacid, 2-methyl-, ethyl ester;2-methylthiazole-4-carboxylic acid ethyl ester;methyl 2-methylthiazole-4-carboxylate
CAS:6436-59-5
MF:C7H9NO2S
MW:171.22
EINECS:
Product Categories:Building Blocks;C3 to C7;Chemical Synthesis;Heterocyclic Building Blocks;Thiazoles
Mol File:6436-59-5.mol
Ethyl 2-methylthiazole-4-carboxylate Structure
Ethyl 2-methylthiazole-4-carboxylate Chemical Properties
Melting point 54-58 °C
Boiling point 242.1±13.0 °C(Predicted)
density 1.198±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
form solid
pka1.10±0.10(Predicted)
AppearanceLight yellow to yellow Solid
InChIInChI=1S/C7H9NO2S/c1-3-10-7(9)6-4-11-5(2)8-6/h4H,3H2,1-2H3
InChIKeyQWWPUBQHZFHZSF-UHFFFAOYSA-N
SMILESS1C=C(C(OCC)=O)N=C1C
CAS DataBase Reference6436-59-5(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-37-24/25
WGK Germany 3
HazardClass IRRITANT
HS Code 29341000
MSDS Information
ProviderLanguage
ALFA English
Ethyl 2-methylthiazole-4-carboxylate Usage And Synthesis
Chemical Propertieslight yellowto brownpowde
UsesEthyl 2-methylthiazole-4-carboxylate is a reactant used in the synthesis of 2,4,5-trisubstituted thiazoles as antituberculosis agents effective against drug resistant tuberculosis.
Synthesis
Ethyl bromopyruvate

70-23-5

Thioacetamide

62-55-5

Ethyl 2-methylthiazole-4-carboxylate

6436-59-5

Ethyl 2-methylthiazole-4-carboxylate was synthesized from ethyl 3-bromopyruvate and thioacetamide in ethanol (EtOH) at 250 W power, 25 kHz frequency, flow rate controlled at 2 mL/min, and reaction time of 1.5 hours.

References[1] Journal of Organic Chemistry, 1997, vol. 62, # 12, p. 3804 - 3805
[2] Organic Letters, 2008, vol. 10, # 8, p. 1565 - 1568
[3] Journal of Organic Chemistry, 2001, vol. 66, # 19, p. 6410 - 6424
[4] Angewandte Chemie - International Edition, 2008, vol. 47, # 46, p. 8950 - 8953
[5] Patent: US2010/249404, 2010, A1. Location in patent: Page/Page column 11
Ethyl 2-methylthiazole-4-carboxylate Preparation Products And Raw materials
Raw materialsEthanol-->Ethyl acetate-->Petroleum ether 60-80 AR 2.5LT-->Ethyl bromopyruvate-->Thioacetamide
Preparation Products2-Methylthiazole-4-carboxamide-->THIAZOLE, 4-(BROMOMETHYL)-2-METHYL-
Tag: Ethyl 2-methylthiazole-4-carboxylate(6436-59-5) Related Product Information
2-(4-TRIFLUOROMETHYL-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER 2-P-TOLYL-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER ETHYL 2-METHYLTHIAZOLE-4-CARBOXYLATE ETHYL 2-(2-THIENYL)-1,3-THIAZOLE-4-CARBOXYLATE Ethyl 2-(3-bromo-4-isobutoxyphenyl)- 4-methyl-5-thiazolecarboxylate ETHYL 2-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLATE Ethyl 2-amino-4-methylthiazole-5-carboxylate ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE ETHYL 4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLATE ETHYL 2-AMINO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE HYDROCHLORIDE 4-TRIFLUOROMETHYLTHIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER ETHYL 2,4-DIMETHYLTHIAZOLE-5-CARBOXYLATE ETHYL 4-METHYLTHIAZOLE-5-CARBOXYLATE ETHYL 4-METHYLTHIAZOLE-5-CARBOXYLATE Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate ETHYL THIAZOLE-4-CARBOXYLATE 4-Thiazolecarboxylic acid