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| | Ethyl 2-amino-4-methylthiazole-5-carboxylate Basic information |
| | Ethyl 2-amino-4-methylthiazole-5-carboxylate Chemical Properties |
| Melting point | 176-180 °C(lit.) | | Boiling point | 313.1±22.0 °C(Predicted) | | density | 1.283±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | solubility | DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS pH 7.2 (1:1): 0.5 mg/ml | | form | powder to crystal | | pka | 3.90±0.10(Predicted) | | color | White to Almost white | | Water Solubility | insoluble | | InChI | InChI=1S/C7H10N2O2S/c1-3-11-6(10)5-4(2)9-7(8)12-5/h3H2,1-2H3,(H2,8,9) | | InChIKey | WZHUPCREDVWLKC-UHFFFAOYSA-N | | SMILES | S1C(C(OCC)=O)=C(C)N=C1N | | CAS DataBase Reference | 7210-76-6(CAS DataBase Reference) |
| | Ethyl 2-amino-4-methylthiazole-5-carboxylate Usage And Synthesis |
| Chemical Properties | off-white powder | | Uses | Ethyl 2-amino-4-methylthiazole-5-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | | Synthesis | Thiourea (2.55 g, 0.033 mol, 1.1 eq.) was added to a solution of ethyl 2-chloro-3-oxobutanoate (5 g, 0.030 mol, 1 eq.) in ethanol (25 mL) at 25 °C. The reaction mixture was heated to reflux and kept for 3 hours. Upon completion of the reaction, the reaction mixture was slowly cooled to 25 °C under continuous stirring to induce precipitation of the product as a white solid. The precipitated solid was collected by filtration through a Büchner funnel and dried under vacuum to afford ethyl 2-amino-4-methylthiazole-5-carboxylate (4.8 g, 64% yield) as a final fine white powder. | | References | [1] Patent: CN108570017, 2018, A. Location in patent: Paragraph 0030; 0031; 0033; 0035; 0037
[2] Chemical Biology and Drug Design, 2016, vol. 87, # 4, p. 508 - 516
[3] Patent: CN102942565, 2016, B. Location in patent: Paragraph 0028-0031; 0087-0088
[4] Archiv der Pharmazie, 2017, vol. 350, # 2,
[5] Acta Poloniae Pharmaceutica - Drug Research, 2017, vol. 74, # 6, p. 1699 - 1709 |
| | Ethyl 2-amino-4-methylthiazole-5-carboxylate Preparation Products And Raw materials |
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