- SevelaMer carbonate
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- $396.00
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2026-08-12
- CAS:845273-93-0
- Min. Order: 1Kg/Bag
- Purity: 98%
- Supply Ability: 1000KG
- Sevelamer carbonate
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-
2026-07-02
- CAS:845273-93-0
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1000kg
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| | Sevelamer carbonate Basic information |
| Product Name: | Sevelamer carbonate | | Synonyms: | 2-Propen-1-amine polymer with (chloromethyl)oxirane carbonate;Sevelamer carbonate;Carbonic acid, compd. with 2-(chloromethyl)oxirane polymer with 2-propen-1-amine;Sevelam;2-Propen-1-amine polymer with (chloromethyl)oxiran;2-Propen-1-aminepolymerwith;carbonic acid,2-(chloromethyl)oxirane,prop-2-en-1-amine;SIM862 Sevelamer Carbonate-----25gm | | CAS: | 845273-93-0 | | MF: | C7H14ClNO4 | | MW: | 211.64 | | EINECS: | 682-521-9 | | Product Categories: | Inhibitors;Pharmaceutical intermediate;Other APIs | | Mol File: | 845273-93-0.mol |  |
| | Sevelamer carbonate Chemical Properties |
| storage temp. | Room Temperature, under inert atmosphere | | solubility | <4.74mg/mL in DMSO | | form | Solid | | color | White to Pale Beige | | Major Application | pharmaceutical (small molecule) | | InChI | InChI=1S/C3H5ClO.C3H7N.CH2O3/c4-1-3-2-5-3;1-2-3-4;2-1(3)4/h3H,1-2H2;2H,1,3-4H2;(H2,2,3,4) | | InChIKey | PADGNZFOVSZIKZ-UHFFFAOYSA-N | | SMILES | C(O)(O)=O.C(C1OC1)Cl.C(=C)CN |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | Sevelamer carbonate Usage And Synthesis |
| Description | Sevelamer carbonate (SC) is a non-absorbed phosphate binding crosslinked polymer, with the same polymeric structure as sevelamer hydrochloride, in which carbonate replaces chloride as the counterion. SC has been found to have the same safety and efficacy profile as Sevelamer HCl in HD patients.
Sevelamer carbonate(Renvela) is a nonaluminum, non-calcium-basedphosphorus binder that traps phosphorus in the bowel through ion exchange and hydrogen binding. This drug replaced sevelamer hydrochloride(Renagel) and has an advantage of not generating an acid load, as its precursor, sevelamer hydrochloride, did. It also has the advantage of lowering LDL cholesterol due to gut binding of bile acids. | | Uses | Control of serum phosphorus in patients with chronic kidney disease (phosphate binder). | | Uses | Sevelamer Carbonate, a non-absorbed polymer is an oral phosphate binder in patients with kidney failure. It is reported that Sevelamer Carbonate is less likely to cause hypercalcemia, low levels of PTH, and progressive coronary and aortic calcification in hemodialysis patients than calcium-based phosphate binders. | | Side effects |
The Common Side Effects of Sevelamer carbonate:
Vomiting (22%), Nausea (20%), Diarrhea (19%), Indigestion (16%), Stomach pain (9%), Feeling gassy (8%), and Constipation (8%).
The Serious Side Effects of Sevelamer carbonate:
Stomach or intestine problems: bowel blockage, bleeding ulcers, severe stomach pain, blood in your stool.
| | Mode of action | The active substance in Sevelamer carbonate Winthrop, sevelamer carbonate, is a phosphate binder. When taken with meals, it attaches in the gut to phosphate from the food, thereby preventing the phosphate from being absorbed into the body and helping to reduce phosphate levels in the blood.
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| | Sevelamer carbonate Preparation Products And Raw materials |
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