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BOC Sciences |
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1-631-485-4226; 16314854226 |
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- L-trans-2,4-PDC
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- $282.00
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2026-04-22
- CAS:64769-66-0
- Purity:
- Supply Ability: 10g
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| | L-trans-Pyrrolidine-2,4-dicarboxylic acid Basic information |
| Product Name: | L-trans-Pyrrolidine-2,4-dicarboxylic acid | | Synonyms: | L-TRANS-4-CARBOXY-L-PROLINE;L-TRANS-PYRROLIDINE-2,4-DICARBOXYLIC ACID;TRANS-4-CARBOXY-L-PROLINE;2,4-Pyrrolidinedicarboxylicacid,(2S,4R)-(9CI);Zinc03796127;(2S,4R)-pyrrolidine-2,4-dicarboxylic acid;(2S,4R)-2,4-Pyrrolidinedicarboxylic acid;2,4-Pyrrolidinedicarboxylic acid, (2S,4R)- | | CAS: | 64769-66-0 | | MF: | C6H9NO4 | | MW: | 159.14 | | EINECS: | | | Product Categories: | PYRROLE;Glutamate receptor | | Mol File: | 64769-66-0.mol |  |
| | L-trans-Pyrrolidine-2,4-dicarboxylic acid Chemical Properties |
| Melting point | 214-217oC | | storage temp. | Store at RT | | solubility | PBS (pH 7.2): 2 mg/ml | | form | White solid. | | color | White | | Water Solubility | Soluble to 100 mM in water | | InChI | InChI=1S/C6H9NO4/c8-5(9)3-1-4(6(10)11)7-2-3/h3-4,7H,1-2H2,(H,8,9)(H,10,11)/t3-,4+/m1/s1 | | InChIKey | NRSBQSJHFYZIPH-DMTCNVIQSA-N | | SMILES | N1C[C@H](C(O)=O)C[C@H]1C(O)=O |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | L-trans-Pyrrolidine-2,4-dicarboxylic acid Usage And Synthesis |
| Description | L-trans-Pyrrolidine-2,4-dicarboxylic acid (L-trans-2,4-PDC) is an inhibitor of L-glutamate transport (Ki = 4.6 μM in rat brain synaptosomes). It inhibits radioligand binding to NMDA receptors by 13% but has no effect on AMPA or kainate receptors when used at a concentration of 100 μM. L-trans-2,4-PDC is neurotoxic to astrocyte-rich and astrocyte-poor rat cortical cultures (EC50s = 320 and 50 μM, respectively), an effect that can be reversed by the NMDA antagonist MK-801 and glutamate-pyruvate transaminase but not the non-NMDA glutamate receptor antagonist CNQX. It induces efflux of the non-metabolizable glutamate analog [3H]-D-aspartate in an extracellular sodium-dependent manner. In vivo, L-trans-2,4-PDC (0.05-0.2 μg/side) prevents amphetamine-induced hyperlocomotion in a dose-dependent manner in rats when injected directly into the nucleus accumbens. It also increases bladder intercontraction interval (ICI) without affecting postvoid residual or basal pressure in rats. | | Uses | L-trans-Pyrrolidine-2,4-dicarboxylic Acid is an inhibitor of the glutamate transporter EAAT. | | Biological Activity | Potent, competitive, transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor. Also available as part of the Excitatory Amino Acid Transporter Inhibitor Tocriset™ . | | storage | Store at RT | | References | [1] RICHARD J. BRIDGES. Conformationally defined neurotransmitter analogs. Selective inhibition of glutamate uptake by one pyrrolidine-2,4-dicarboxylate diastereomer[J]. Journal of Medicinal Chemistry, 1991, 34 2: 717-725. DOI:10.1021/jm00106a037.
[2] Blitzblau, R., Gupta, S., Djali, S., et al. The glutamate transport inhibitor L-trans-pyrrolidine-2,4-dicarboxylate indirectly evokes NMDA receptor mediated neurotoxicity in rat cortical cultures. Eur. J. Neurosci. 8(9), 1840-1852 (1996).
[3] David, H.N., Thévenoux, A., and Abraini, J.H. Inhibition of the glutamate transporter by L-trans-PDC in the nucleus accumbens prevents the locomotor response to amphetamine. Neuropharmacology 41(3), 409-411 (2001).
[4] MASASHI HONDA. Supraspinal and spinal effects of L-trans-PDC, an inhibitor of glutamate transporter, on the micturition reflex in rats.[J]. Neurourology and Urodynamics, 2013, 32 7: 1026-1030. DOI:10.1002/nau.22351. |
| | L-trans-Pyrrolidine-2,4-dicarboxylic acid Preparation Products And Raw materials |
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