RD-3-0028 manufacturers
- RD3-0028
-
- $1520.00
-
2026-07-27
- CAS:3886-39-3
- Purity:
- Supply Ability: 10g
- RD3-0028
-
- $1520.00
-
2026-07-27
- CAS:3886-39-3
- Purity:
- Supply Ability: 10g
- RD3-0028
-
- $1520.00
-
2025-07-31
- CAS:3886-39-3
- Purity:
- Supply Ability: 10g
|
| | RD-3-0028 Basic information |
| Product Name: | RD-3-0028 | | Synonyms: | 1,4-Dihydro-2,3-benzodithiin;RD-3-0028;2,3-Benzodithiin, 1,4-dihydro-;RD-3-0028,RD3 0028,RD30028;1,4-Dihydro-2,3-benzodithiine | | CAS: | 3886-39-3 | | MF: | C8H8S2 | | MW: | 168.28 | | EINECS: | | | Product Categories: | | | Mol File: | 3886-39-3.mol |  |
| | RD-3-0028 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO |
| | RD-3-0028 Usage And Synthesis |
| Uses | RD3-0028 is a potent and selective inhibitor of RSV replication with an EC50 of 4.5 μM. | | in vivo | Aerosols generated from reservoirs containing RD3-0028 (7 mg/mL) administered for 2 h twice daily for 3 days significantly reduces the pulmonary titer of RSV-infected mice. It is clear that the minimal effective dose of RD3-0028 for RSV-infected mice is significantly less than that of ribavirin, the only compound currently available for use against RSV disease. Furthermore, the RD3-0028 aerosol administration protect the lungs of infected, CYP-treated mice against tissue damage, as evidenced by the preservation of the lung architecture and a reduction in pulmonary inflammatory infiltrates. RD3-0028 aerosol is not toxic for mice at the therapeutic dose[2]. The plasma concentration of RD3-0028 is maintained at the same level from 5 min to 1 h, and decreases with a half-life of 2.2 h for 1±8 h. The excretion of radioactivity in the urine and faeces at 24 h after aerosol treatment is 89.3 and 4.5%, respectively, indicating that almost all the radioactivity is rapidly excreted in the urine. The excretion of total radioactivity is 98.9% within 168 h[3]. | | References | [1] Watanabe W, et al. Novel anti-respiratory syncytial(RS) viral compounds: benzodithiin derivatives. Biochem Biophys Res Commun. 1998 Aug 28;249(3):922-6. DOI:10.1006/bbrc.1998.9222
[2] Sudo K, et al. Efficacy of RD3-0028 aerosol treatment against respiratory syncytial virus infection in immunosuppressed mice. Antimicrob Agents Chemother. 1999 Apr;43(4):752-7. DOI:10.1128/AAC.43.4.752
[3] Sudo K, et al. Pharmacokinetics of a benzodithiin (RD3-0028) following aerosol treatment in rat. DOI:10.1080/00498250110079158 |
| | RD-3-0028 Preparation Products And Raw materials |
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