- Hirsutine
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2026-07-10
- CAS:7729-23-9
- Purity: 98%
- Supply Ability: 1000KGS
- Hirsutine
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- $89.00
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2026-06-02
- CAS:7729-23-9
- Purity: 99.98%
- Supply Ability: 10g
- Hirsutine
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2024-04-12
- CAS:7729-23-9
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 2000ton
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| | Hirsutine Basic information |
| Product Name: | Hirsutine | | Synonyms: | HIRSUTINE;(e)-16,17-didehydro-17-methoxy-17,18-seco-3-beta-yohimban-16-carboxylicacid;16e)-;18-seco-3-beta-yohimban-16-carboxylicacid,16,17-didehydro-17-methoxy-1met;corynan-16-carboxylicacid,16,17-didehydro-17-methoxy-,methylester,(3-bet;Methyl (E)-2-[(2S,3R,12bR)-3-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo[3,2-h]quinolizin-2-yl]-3-methoxyprop-2-enoate;(3β,16E)-16,17-Didehydro-17-methoxycorynan-16-carboxylic acid methyl ester;Methyl (E)-2-[(2 | | CAS: | 7729-23-9 | | MF: | C22H28N2O3 | | MW: | 368.47 | | EINECS: | | | Product Categories: | | | Mol File: | 7729-23-9.mol |  |
| | Hirsutine Chemical Properties |
| Melting point | 101 °C | | Boiling point | 531.7±50.0 °C(Predicted) | | density | 1.20±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | 18.13±0.60(Predicted) | | color | White to off-white | | InChIKey | NMLUOJBSAYAYEM-YUPRPPKRNA-N | | SMILES | [C@]12([H])C[C@@H]([C@@H](CC)CN1CCC1C3=C(C=CC=C3)NC2=1)/C(=C\OC)/C(=O)OC |&1:0,3,4,r| |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | Hirsutine Usage And Synthesis |
| Chemical Properties | White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Uncaria rhynchophylla (Miq.) Miq. ex Havil. | | Uses | Hirsutine, an indole alkaloid of Uncaria rhynchophylla, exhibits anti-cancer activity. Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity[1][2][3]. | | Biological Activity | Hirsutine is a brain penetrant alkaloid from Uncaria rhynchophylla th at exhibit anti-cancer, cardioprotective, anti-hypertensive, and anti-arrhythmic activities. It appears th at hirsutine induces apoptosis in lung cancer cells through opening of mitochondrial permeability transition pore (mPTP). Hirsutine exhibit potent anti-dengue virus activity. | | in vivo | Hirsutine induces mPTP-dependent apoptosis through ROCK1/PTEN/PI3K/GSK3β pathway in human lung cancer cells[3]. | | References | [1] Hishiki T, et al. Hirsutine, an Indole Alkaloid of Uncaria rhynchophylla, Inhibits Late Step in Dengue Virus Lifecycle. Front Microbiol. 2017 Aug 30;8:1674. DOI:10.3389/fmicb.2017.01674
[2] Huang QW, et al. [Hirsutine induces apoptosis of human breast cancer MDA-MB-231 cells through mitochondrial pathway]. Sheng Li Xue Bao. 2018 Feb 25;70(1):40-46. PMID:29492513
[3] Zhang R, et al. Hirsutine induces mPTP-dependent apoptosis through ROCK1/PTEN/PI3K/GSK3β pathway in human lung cancer cells. Cell Death Dis. 2018 May 22;9(6):598. DOI:10.1038/s41419-018-0641-7 |
| | Hirsutine Preparation Products And Raw materials |
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