(3aS)-4,8-Dimethyl-3-methylene-4β-ethenyl-3aβ,4,5,8bβ-tetrahydrobenzo[1,2-b:3,4-b']difuran-2(3H)-one

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(3aS)-4,8-Dimethyl-3-methylene-4β-ethenyl-3aβ,4,5,8bβ-tetrahydrobenzo[1,2-b:3,4-b']difuran-2(3H)-one manufacturers

(3aS)-4,8-Dimethyl-3-methylene-4β-ethenyl-3aβ,4,5,8bβ-tetrahydrobenzo[1,2-b:3,4-b']difuran-2(3H)-one Basic information

Product Name:	(3aS)-4,8-Dimethyl-3-methylene-4β-ethenyl-3aβ,4,5,8bβ-tetrahydrobenzo[1,2-b:3,4-b']difuran-2(3H)-one
Synonyms:	(3aS)-4,8-Dimethyl-3-methylene-4β-ethenyl-3aβ,4,5,8bβ-tetrahydrobenzo[1,2-b:3,4-b']difuran-2(3H)-one;(3aS)-4β-Vinyl-3a,4,5,8bβ-tetrahydro-4,8-dimethyl-3-methylenebenzo[1,2-b:3,4-b']difuran-2(3H)-one;(3aS)-4,8-Dimethyl-3-methylene-4β-ethenyl-3aβ,4,5,8bβ-tetrahydrobenzo[1,2-b;3,4-b']difuran-2(3H)-one;Reaxys ID: 5276986;Benzo[1,2-b:3,4-b']difuran-2(3H)-one, 4-ethenyl-3a,4,5,8b-tetrahydro-4,8-dimethyl-3-methylene-, (3aS,4R,8bR)-;(3aS)-4,8-Dimethyl-3-methylene-4β-ethenyl-3aβ,4,5,8bβ-tetrahydrobenzo[1,2-b:3,4-b]difuran-2(3H)-one;(3aS,4R,8bR)-4,8-Dimethyl-3-methylene-4-vinyl-3a,4,5,8b-tetrahydrobenzo[1,2-b:3,4-b']difuran-2(3H)-one
CAS:	957-66-4
MF:	C15H16O3
MW:	244.29
EINECS:
Product Categories:	Sesquiterpenoids
Mol File:	957-66-4.mol

(3aS)-4,8-Dimethyl-3-methylene-4β-ethenyl-3aβ,4,5,8bβ-tetrahydrobenzo[1,2-b:3,4-b']difuran-2(3H)-one Chemical Properties

Melting point	118-121℃
Boiling point	378.8±42.0 °C(Predicted)
density	1.16±0.1 g/cm3 (20 ºC 760 Torr)
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form	Powder
color	White to off-white

Safety Information

MSDS Information

(3aS)-4,8-Dimethyl-3-methylene-4β-ethenyl-3aβ,4,5,8bβ-tetrahydrobenzo[1,2-b:3,4-b']difuran-2(3H)-one Usage And Synthesis

Chemical Properties	Off-white needle-like crystals, soluble in methanol, ethanol, DMSO and other organic solvents, from Camphoraceae (Lauraceae) Uva Ursi Lindera strychnifolia Vill. root fine trace Neolitsea aciculata Koidz. root, trunk NANRENSHAN NEW WOOD JIANG ZI Neolitsea Roots of Neolitsea villosa (Blume) Merr.
Uses	Isolinderalactone suppresses human glioblastoma growth and angiogenic activity through the inhibition of VEGFR2 activation in endothelial cells[1]. Isolinderalactone suppresses the expression of B-cell lymphoma 2 (Bcl-2), survi
Definition	ChEBI: Isolinderalactone is a member of benzofurans. It has a role as a metabolite.
IC 50	VEGFR2; Bcl-2
References	[1] Park JH, et al. Isolinderalactone suppresses human glioblastoma growth and angiogenic activity in 3D microfluidic chip and in vivo mouse models.Cancer Lett. 2020;478:71-81. DOI:10.1016/j.canlet.2020.03.009 [2] Hwang JY, et al. Isolinderalactone regulates the BCL-2/caspase-3/PARP pathway and suppresses tumor growth in a human glioblastoma multiforme xenograft mouse model.Cancer Lett. 2019;443:25-33. DOI:10.1016/j.canlet.2018.11.027

(3aS)-4,8-Dimethyl-3-methylene-4β-ethenyl-3aβ,4,5,8bβ-tetrahydrobenzo[1,2-b:3,4-b']difuran-2(3H)-one Preparation Products And Raw materials

Tag:(3aS)-4,8-Dimethyl-3-methylene-4β-ethenyl-3aβ,4,5,8bβ-tetrahydrobenzo[1,2-b:3,4-b']difuran-2(3H)-one(957-66-4) Related Product Information

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