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| | 3-Boc-amino-pyrrolidin-2-one Basic information |
| Product Name: | 3-Boc-amino-pyrrolidin-2-one | | Synonyms: | Carbamic acid, N-(2-oxo-3-pyrrolidinyl)-, 1,1-dimethylethyl ester;tert-Butyl (2-oxopyrrolidin-3-yl);tert-butyl N-(2-oxopyrrolidin-3-yl)carbamate;3-BO-C-aminopyrolidine-2-one;3-Boc-amino-pyrrolidin-2-one | | CAS: | 99780-97-9 | | MF: | C9H16N2O3 | | MW: | 200.23 | | EINECS: | | | Product Categories: | | | Mol File: | 99780-97-9.mol |  |
| | 3-Boc-amino-pyrrolidin-2-one Chemical Properties |
| Boiling point | 394.0±31.0 °C(Predicted) | | density | 1.13±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 11.05±0.20(Predicted) | | Appearance | White to off-white Solid |
| | 3-Boc-amino-pyrrolidin-2-one Usage And Synthesis |
| Synthesis | To a mixed methanol and triethylamine solution (9:1, 130 mL, v/v) of 3-aminopyrrolidin-2-one (39) (2.8 g, 28 mmol), di-tert-butyl dicarbonate (6.7 g, 30.8 mmol) was added. The reaction mixture was stirred overnight at room temperature and then heated to reflux for 2 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure and the resulting solid was collected by filtration and washed with ether to afford 3-(Boc-amino)pyrrolidin-2-one in 97% yield. | | References | [1] Patent: US2005/165065, 2005, A1. Location in patent: Page/Page column 24
[2] Patent: WO2017/75056, 2017, A1. Location in patent: Paragraph 0371
[3] Journal of Medicinal Chemistry, 1986, vol. 29, # 2, p. 251 - 260
[4] Patent: US6441017, 2002, B1 |
| | 3-Boc-amino-pyrrolidin-2-one Preparation Products And Raw materials |
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