(S)-Boc-3-amino-2-pyrrolidinone manufacturers
|
| | (S)-Boc-3-amino-2-pyrrolidinone Basic information |
| Product Name: | (S)-Boc-3-amino-2-pyrrolidinone | | Synonyms: | (S)-(-)-3-BOC-AMINOPYRROLIDIN-2-ONE;CarbaMic acid, N-[(3S)-2-oxo-3-pyrrolidinyl]-, 1,1-diMethylethyl ester;tert-butyl 2-oxopyrrolidin-3-ylcarbaMate;(S)-tert-butyl 2-oxopyrrolidin-3-ylcarbaMate;(2-oxopyrrolidin-3-(S)-yl)carbaMic acid tert-butyl ester;2-Methyl-2-propanyl [(3S)-2-oxo-3-pyrrolidinyl]carbaMate;tert-butyl N-[(3S)-2-oxopyrrolidin-3-yl]carbamate;(S)-3-(Boc-amino)-2-pyrrolidone | | CAS: | 92235-34-2 | | MF: | C9H16N2O3 | | MW: | 200.24 | | EINECS: | | | Product Categories: | pharmacetical;Amino Acids & Deriv.;CHIRAL CHEMICALS | | Mol File: | 92235-34-2.mol |  |
| | (S)-Boc-3-amino-2-pyrrolidinone Chemical Properties |
| Melting point | 168.0-170.3 °C(Solv: ethyl acetate (141-78-6); ligroine (8032-32-4)) | | Boiling point | 394.0±31.0 °C(Predicted) | | density | 1.13±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 11.05±0.20(Predicted) | | Appearance | White to off-white Solid |
| | (S)-Boc-3-amino-2-pyrrolidinone Usage And Synthesis |
| Synthesis | Step 1: (S)-3-Amino-2-pyrrolidinone (3.1 g, 32 mmol) was dissolved in methanol (130 mL) at room temperature and triethylamine (16 mL) and di-tert-butyl dicarbonate (7.7 g, 35.2 mmol) were added sequentially. The reaction mixture was stirred at room temperature overnight and then heated to reflux for 2 hours. After completion of the reaction, the solvent was removed by concentration under reduced pressure and the residue was purified by column chromatography (eluent: ethyl acetate) to afford (S)-tert-butoxycarbonyl-3-amino-2-pyrrolidinone (5.0 g, 78% yield) as a white solid. | | References | [1] Patent: WO2008/33562, 2008, A2. Location in patent: Page/Page column 63
[2] Patent: US2009/76005, 2009, A1. Location in patent: Page/Page column 29; 30
[3] Patent: WO2007/126871, 2007, A1. Location in patent: Page/Page column 61-62 |
| | (S)-Boc-3-amino-2-pyrrolidinone Preparation Products And Raw materials |
|