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N-(2-Aminophenyl)-N'-phenylheptanediamide

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N-(2-Aminophenyl)-N'-phenylheptanediamide manufacturers

  • NKL 22
  • NKL 22 pictures
  • $29.00
  • 2026-07-14
  • CAS:537034-15-4
  • Purity: 96.24%
  • Supply Ability: 10g
N-(2-Aminophenyl)-N'-phenylheptanediamide Basic information
Product Name:N-(2-Aminophenyl)-N'-phenylheptanediamide
Synonyms:N-(2-Aminophenyl)-N'-phenylheptanediamide;N1-(2-AMinophenyl)-N7-phenylheptanediaMide;NKL 22;HDAC inhibitor IV;Histone Deacetylase Inhibitor IV;HDACi-4b;HISTONE DEACETYLASE INHIBITOR IV;NKL22;NKL-22;NKL 22;NKL 22, >98%
CAS:537034-15-4
MF:C19H23N3O2
MW:325.4
EINECS:
Product Categories:Amines;Aromatics;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:537034-15-4.mol
N-(2-Aminophenyl)-N'-phenylheptanediamide Structure
N-(2-Aminophenyl)-N'-phenylheptanediamide Chemical Properties
Melting point 159-161°C
Boiling point 627.9±40.0 °C(Predicted)
density 1.212±0.06 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility DMSO, Methanol
form Beige solid
pka14+-.0.70(Predicted)
color Off-White to Pale Beige
InChI1S/C19H23N3O2/c20-16-11-7-8-12-17(16)22-19(24)14-6-2-5-13-18(23)21-15-9-3-1-4-10-15/h1,3-4,7-12H,2,5-6,13-14,20H2,(H,21,23)(H,22,24)
InChIKeyZAIULUYKQLVQFH-UHFFFAOYSA-N
Safety Information
WGK Germany WGK 2
Storage Class11 - Combustible Solids
MSDS Information
N-(2-Aminophenyl)-N'-phenylheptanediamide Usage And Synthesis
Chemical PropertiesOff-White Solid
UsesHistone deacetylase inhibitor IV. A cell-permeable pimeloylanilide compound that acts as a FXN-(frataxin gene) specific HDAC inhibitor. Reverses the silencing of FXN transcription in FRDA (Friedrich’s ataxia) cells due to hypoacetylation of histones H3 and H4.
General DescriptionA cell-permeable pimeloylanilide compound that acts as a FXN- (frataxin gene) specific HDAC (histone deacetylase) inhibitor. Reverses the silencing of FXN transcription in FRDA (Friedreich′s ataxia) cells (~3-fold increase of FXN mRNA at 5 μM in primary FRDA lymphocytes and ~3-fold frataxin expression in FRDA cell line at 2.5 μM) due to hypoacetylation of histones H3 and H4 by increasing acetylation at H3K14, H4K5 and H4K12, without significant changes in acetylation at H3K9, H4K8 and H4K16. In comparison, Trichostatin-A (Cat. No. 647925 and 647926) and SAHA, two other commonly used HDAC inhibitors, exhibit no effect on FXN transcription.
Biochem/physiol ActionsCell permeable: yes
IC 50HDAC1: 0.199 μM (IC50); HDAC2: 1.59 μM (IC50); HDAC3: 0.069 μM (IC50); HDAC8: 5 μM (IC50)
N-(2-Aminophenyl)-N'-phenylheptanediamide Preparation Products And Raw materials
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