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| | 5,6-difluoro-indoline-2,3-dione Basic information |
| Product Name: | 5,6-difluoro-indoline-2,3-dione | | Synonyms: | skln-0003;5,6-difluoro-2,3-dihydro-1H-indole-2,3-dione;5,6-Difluoroindole-2,3-dione;5,6-Difluoroisatine;5,6-DifL;5,6-difluoro-indoline-2,3-dione ISO 9001：2015 REACH;1H-Indole-2,3-dione, 5,6-difluoro- | | CAS: | 774-47-0 | | MF: | C8H3F2NO2 | | MW: | 183.11 | | EINECS: | | | Product Categories: | | | Mol File: | 774-47-0.mol |  |
| | 5,6-difluoro-indoline-2,3-dione Chemical Properties |
| Melting point | 218-220℃ | | density | 1.578±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 7.32±0.20(Predicted) | | form | solid | | color | Orange |
| | 5,6-difluoro-indoline-2,3-dione Usage And Synthesis |
| Synthesis | GENERAL PROCEDURE: To a stirred 18.1 M aqueous sulfuric acid solution (0.68 mL/mmol), isonitrosoacetanilide (1 equiv.) was added in batches at 60 °C. The reaction mixture was placed in a heating block and stirred at an internal temperature of 80 °C for 30 min, followed by cooling to room temperature. The reaction solution was slowly poured into a saturated ice-water mixture (5 mL/g) and stirred at room temperature for 10 minutes. The resulting solid was collected by filtration, dried and purified according to standard methods. | | References | [1] Synlett, 2016, vol. 27, # 10, p. 1516 - 1520
[2] Journal of Organic Chemistry, 1958, vol. 23, p. 1858,1860 |
| | 5,6-difluoro-indoline-2,3-dione Preparation Products And Raw materials |
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