BRICICLIB
| 中文名称 | BRICICLIB |
|---|---|
| 中文同义词 | 布瑞西利, >98%;布瑞西利;BRICICLIB (SYNONYMS: ON 014185);化合物BRICICLIB;(E)-2-甲氧基-5-((((2,4,6-三甲氧基苯乙烯基)磺酰基)甲基)苯基 磷酸二氢酯;化合物BRICICLIB,10 MM DMSO 溶液;化合物:Briciclib CAS:865783-99-9;化合物：Briciclib CAS:865783-99-9 |
| 英文名称 | Phenol, 2-Methoxy-5-[[[(1E)-2-(2,4,6-triMethoxyphenyl)ethenyl]sulfonyl]Methyl]-, 1-(dihydrogen phosphate) |
| 英文同义词 | Phenol, 2-Methoxy-5-[[[(1E)-2-(2,4,6-triMethoxyphenyl)ethenyl]sulfonyl]Methyl]-, 1-(dihydrogen phosphate);Briciclib,ON-014185;ON-014185;(E)-5-[[(2,4,6-Trimethoxystyryl)sulfonyl]methyl]-2-methoxyphenyl dihydrogen phosphate;2-Methoxy-5-({[(E)-2-(2,4,6-trimethoxyphenyl)vinyl]sulfonyl}methy l)phenyl dihydrogen phosphate;Briciclib(ON 013105,ON 014185);Briciclib, >98%;ON013105;ON014185;ON-013105;ON-014185 |
| CAS号 | 865783-99-9 |
| 分子式 | C19H23O10PS |
| 分子量 | 474.42 |
| EINECS号 | |
| 相关类别 | 小分子抑制剂;API |
| Mol文件 | 865783-99-9.mol |
| 结构式 |  |
BRICICLIB 性质
| 储存条件 | Sealed in dry,Room Temperature |
|---|---|
| 溶解度 | DMF：30mg/mL；二甲基亚砜：30mg/mL |
| 形态 | 结晶固体 |
| 颜色 | 白色至米白色 |
| InChI | InChI=1S/C19H23O10PS/c1-25-14-10-17(27-3)15(18(11-14)28-4)7-8-31(23,24)12-13-5-6-16(26-2)19(9-13)29-30(20,21)22/h5-11H,12H2,1-4H3,(H2,20,21,22)/b8-7+ |
| InChIKey | LXENKEWVEVKKGV-BQYQJAHWSA-N |
| SMILES | C1(OP(O)(O)=O)=CC(CS(/C=C/C2=C(OC)C=C(OC)C=C2OC)(=O)=O)=CC=C1OC |
Briciclib (ON-014185)是ON-013100的水溶性衍生物。ON-013100是一种可与eIF4E结合并抑制其活性的小分子化合物。
eIF4E
Briciclib has the potential in targeting eIF4E. Briciclib shows inhibitory activity against the proliferation of mantle cell leukemia (EKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines with GI 50 s of 9.8-12.2 nM, and with no toxicity on normal endothelial cells. Briciclib dose-dependently reduces the expression of cyclin D1 and c-Myc in breast and MCL cancer cell lines within 8 hours.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/09/19 | S6533 | BRICICLIB Briciclib | 865783-99-9 | 2mg | 795.41元 |
| 2025/05/22 | XW86578399903 | 布瑞西利 | 865783-99-9 | 5MG | 181元 |