| Company Name: |
Sigma-Aldrich |
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
- Sutezolid
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- $55.00
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2026-05-11
- CAS:168828-58-8
- Purity: 99.20%
- Supply Ability: 10g
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| | PNU 100480 Basic information |
| Product Name: | PNU 100480 | | Synonyms: | PNU 100480;(S)-N-[[3-[3-Fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-acetamide;(S)-N-((3-(3-fluoro-4-thiomorpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide;(S)-N-((3-(3-fluoro-4-thiomorpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide(WXC06631);PF-02341272;Sutezolid (PNU-100480, PF-02341272);PNU-100480; U-100480; PF-02341272;U-100480 | | CAS: | 168828-58-8 | | MF: | C16H20FN3O3S | | MW: | 353.41 | | EINECS: | | | Product Categories: | | | Mol File: | 168828-58-8.mol |  |
| | PNU 100480 Chemical Properties |
| Melting point | 186-187°C | | Boiling point | 609.0±55.0 °C(Predicted) | | density | 1.321±0.06 g/cm3(Predicted) | | storage temp. | room temp | | solubility | DMSO: soluble20mg/mL, clear | | pka | 15.53±0.46(Predicted) | | form | powder | | color | white to beige | | Optical Rotation | [α]/D -8 to -12°, c = 1 in chloroform-d | | InChI | 1S/C16H20FN3O3S/c1-11(21)18-9-13-10-20(16(22)23-13)12-2-3-15(14(17)8-12)19-4-6-24-7-5-19/h2-3,8,13H,4-7,9-10H2,1H3,(H,18,21)/t13-/m0/s1 | | InChIKey | FNDDDNOJWPQCBZ-ZDUSSCGKSA-N | | SMILES | FC1=CC(N(C[C@H](CNC(C)=O)O2)C2=O)=CC=C1N3CCSCC3 |
| Hazard Codes | Xn | | Risk Statements | 22 | | Safety Statements | 45 | | WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral |
| | PNU 100480 Usage And Synthesis |
| Description | PNU 100480 is an oxazolidinone antibiotic that is active against multidrug resistant tuberculosis. It inhibits the growth of M. tuberculosis replicating and nonreplicating strains (MIC = ~400 ng/ml for both) and of clinical isolates that are susceptible or resistant to a combination of isoniazid , rifampin (rifampicin; ), ethambutol , and streptomycin (; MICs = ≤0.0625-0.5 mg/L). It also inhibits the growth of P. insidiosum and P. aphanidermatum clinical isolates (MICs = 4-64 μg/ml). PNU 100480 (100 mg/kg per day) decreases the number of colony forming units (CFU) in the lung in a mouse model of systemic nonreplicating M. tuberculosis infection. | | Uses | Sutezolid is an oxazolidinone antibacterial agent analog. Sutezolid is a promising antimycobacterial agent (tuberculostatic). | | Biochem/physiol Actions | Sutezolid (PNU 100480) is an oxazolidinone antimicrobial. Sutezolid inhibits protein synthesis by inhibiting bacterial mRNA translation. Sutezolid is being investigated for the treatment of multiple drug–resistant and extensively drug-resistant tuberculosis. The compound is a less toxic and more potent derivative of linezolid. | | in vivo | Sutezolid (PNU-100480) is a thiomorpholinyl analog of linezolid with superior efficacy against M. tuberculosis in the hollow-fiber, mouse, and whole-blood models[3]. | | IC 50 | Oxazolidinone | | References | [1] J W C ALFFENAAR. Susceptibility of clinical Mycobacterium tuberculosis isolates to a potentially less toxic derivate of linezolid, PNU-100480.[J]. Antimicrobial Agents and Chemotherapy, 2011, 55 3: 1287-1289. DOI: 10.1128/aac.01297-10
[2] MING ZHANG. In vitro and in vivo activities of three oxazolidinones against nonreplicating Mycobacterium tuberculosis.[J]. Antimicrobial Agents and Chemotherapy, 2014: 3217-3223. DOI: 10.1128/aac.02410-14
[3] ERICO S LORETO. In Vitro Activities of Miltefosine and Antibacterial Agents from the Macrolide, Oxazolidinone, and Pleuromutilin Classes against Pythium insidiosum and Pythium aphanidermatum.[J]. Antimicrobial Agents and Chemotherapy, 2018, 62 3. DOI: 10.1128/aac.01678-17 |
| | PNU 100480 Preparation Products And Raw materials |
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