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| | (S)-1-Methylpiperidine-2-carboxylic acid Basic information |
| Product Name: | (S)-1-Methylpiperidine-2-carboxylic acid | | Synonyms: | (S)-1-Methylpiperidine-2-carboxylic acid;(S)-1-methyl-2-Piperidinecarboxylic acid;(S)-1-Methylpiperidine-2-carboxylic acid41447-18-1; (-)-(2S)-1-methylpiperidine-2-carboxylic acid;2-Piperidinecarboxylic acid, 1-methyl-, (2S)-;Piperidinium,2-carboxy-1-methyl-,innersalt,(2S)-;Cyclohepta[c]pyrazole-3-carboxylicacid,2,4,5,6,7,10-hexahydro-,ethylester;Pyrazino[2,3-f][1,15]phenanthroline | | CAS: | 41447-18-1 | | MF: | C7H13NO2 | | MW: | 143.18 | | EINECS: | | | Product Categories: | | | Mol File: | 41447-18-1.mol |  |
| | (S)-1-Methylpiperidine-2-carboxylic acid Chemical Properties |
| Melting point | 213-214 °C (decomp) | | Boiling point | 246.1±33.0 °C(Predicted) | | density | 1.103±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 2.48±0.20(Predicted) | | Appearance | White to off-white Solid | | Optical Rotation | Consistent with structure |
| | (S)-1-Methylpiperidine-2-carboxylic acid Usage And Synthesis |
| Synthesis | To a 25 mL three-necked round-bottomed flask was added piperidine-2-carboxylic acid (975 mg, 7.56 mmol), aqueous formaldehyde (37 wt%, 2.0 mL) and formic acid (2.6 mL). The reaction mixture was heated to reflux with stirring and the reaction temperature was maintained for 5 hours. The reaction process was monitored by liquid chromatography-mass spectrometry (LCMS). After completion of the reaction, the reaction mixture was concentrated under reduced pressure using a rotary evaporator. The concentrated residue was co-milled with 30 mL of ether (Et2O) to afford 1-methylpiperidine-2-carboxylic acid as a white solid (0.5 g, 41% yield). | | References | [1] Patent: WO2007/87442, 2007, A2. Location in patent: Page/Page column 101 |
| | (S)-1-Methylpiperidine-2-carboxylic acid Preparation Products And Raw materials |
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