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| | 8-Chloroadenosine-3',5'-cyclic monophosphorothioate, SP-isomer sodium salt Basic information |
| Product Name: | 8-Chloroadenosine-3',5'-cyclic monophosphorothioate, SP-isomer sodium salt | | Synonyms: | ADENOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE, 8-CHLORO-, SP-ISOMER, SODIUM SALT;SP-8-CL-CAMPS, NA;SP-8-CL-CAMPS SODIUM SALT;8-chloroadenosine-3’,5’-cyclicmonophosphorothioate;8-chloroadenosine-3’,5’-cyclicmonophosphorothioate,sp-isomer(sp-8-cl-camps);8-Chloroadenosine-3'',5''-cyclic monophosphothioate sodium salt Sp isomer;Sp-8-Cl-cAMPS;ADENOSINE, 8-CHLORO-,CYCLIC 3',5'-[HYDROGEN (S)-P... | | CAS: | 142754-28-7 | | MF: | C10H10ClN5NaO5PS | | MW: | 401.7 | | EINECS: | | | Product Categories: | | | Mol File: | 142754-28-7.mol |  |
| | 8-Chloroadenosine-3',5'-cyclic monophosphorothioate, SP-isomer sodium salt Chemical Properties |
| | 8-Chloroadenosine-3',5'-cyclic monophosphorothioate, SP-isomer sodium salt Usage And Synthesis |
| Uses | Sp-8-Cl-cAMPS is an analog of cAMP (HY-B1511) and a derivative of Sp-8-Cl-cAMP. Sp-8-Cl-cAMPS inhibits the growth of human leukemia cell HL-60 and colon cancer cell LS-174T, with IC50 of 8-100 μM. Sp-8-Cl-cAMPS activates the protein kinases cAKI and cAKII, with Ka of 0.25 and 3.2 μM[1]. | | References | [1] Yokozaki H, et al., Unhydrolyzable analogues of adenosine 3':5'-monophosphate demonstrating growth inhibition and differentiation in human cancer cells. Cancer Res. 1992 May 1;52(9):2504-8. PMID:1314695 |
| | 8-Chloroadenosine-3',5'-cyclic monophosphorothioate, SP-isomer sodium salt Preparation Products And Raw materials |
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