8-Chloroadenosine manufacturers
- 8-Chloroadenosine
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- $10.00
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2023-02-13
- CAS:34408-14-5
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 50MT
- 8-Chloroadenosine
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-
2023-02-13
- CAS:34408-14-5
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 20MT
- 8-Chloroadenosine
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- $15.00
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2022-02-25
- CAS:34408-14-5
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 1000Kg
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| | 8-Chloroadenosine Basic information |
| Product Name: | 8-Chloroadenosine | | Synonyms: | 8-Chloro-D-adenosine;8-Cl-rA;8-CL-ADO;8-CHLOROADENOSINE;ADENOSINE, 8-CHLORO;6-Amino-8-chloropurine riboside;2-(6-amino-8-chloro-9-purinyl)-5-(hydroxymethyl)oxolane-3,4-diol;8-CHLOROADENOSINE USP/EP/BP | | CAS: | 34408-14-5 | | MF: | C10H12ClN5O4 | | MW: | 301.69 | | EINECS: | | | Product Categories: | | | Mol File: | 34408-14-5.mol |  |
| | 8-Chloroadenosine Chemical Properties |
| Melting point | 189-191 °C | | Boiling point | 707.4±70.0 °C(Predicted) | | density | 2.19±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | Soluble to 20 mM in water with gentle warming and to 100 mM in DMSO | | pka | 12.90±0.70(Predicted) | | form | Crystalline solid. | | color | White to off-white | | InChI | InChI=1S/C10H12ClN5O4/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,13,14)/t3-,5-,6-,9-/m1/s1 | | InChIKey | MHDPPLULTMGBSI-UUOKFMHZSA-N | | SMILES | OC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)N)N=C2Cl)[C@H](O)[C@@H]1O |
| | 8-Chloroadenosine Usage And Synthesis |
| Description |
8-Chloroadenosine is a nucleoside analog; metabolized in vivo to 8-Chloro-ATP. Incorporates into RNA during transcription and inhibits RNA synthesis. Exhibits cytotoxicity in MM.1S, RPMI-8226 and U266 cancer cell lines; induces G2/M cell cycle arrest and mitotic catastrophe in A549 and H1299 cells.
| | Uses | 8-Chloroadenosine (cas# 34408-14-5) is a useful research chemical.8-Chloroadenosine is an analog of adenosine which depletes ATP and inhibits tumor growth in hematological malignancies as well as in lung and breast cancer cell lines. | | Biological Activity | 8-Chloroadenosine (8-Cl-Ado), an adenosine analog, is a potential antitumor drug that is currently in phase-I clinical trials for chronic lymphocytic leukemia (CLL). It has been reported that 8-Cl-Ado inhibits cancer cell growth and induces apoptosis in Granta, JeKo, Mino, and SP-53 MCL cell lines by inhibition of both DNA and RNA syntheses. In addition, 8-Cl-Ado induces autophagy in primary CLL cells5 and in MCF-7 and BT-474 breast cancer cells6. Research has shown that 8-Cl-Ado inhibits the proliferation and migration of SK-BR-3, MDA-MB-231, and MCF-7 breast cancer cells by targeting the RNA-editing enzyme ADAR1[1]. | | storage | Store at -20°C | | References | [1] Hong-Yue Ding. “8-Chloro-Adenosine Inhibits Proliferation of MDA-MB-231 and SK-BR-3 Breast Cancer Cells by Regulating ADAR1/p53 Signaling Pathway.” Cell Transplantation (2020): 963689720958656.
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| | 8-Chloroadenosine Preparation Products And Raw materials |
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