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Syk Inhibitor II manufacturers
- Syk Inhibitor II
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2026-07-29
- CAS:227449-73-2
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1000kg
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| | Syk Inhibitor II Basic information |
| Product Name: | Syk Inhibitor II | | Synonyms: | Syk Inhibitor II;Syk Inhibitor II (hydrochloride);2-[(2-Aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-5-pyrimidinecarboxamide Hydrochloride;Syk Inhibitor II dihydrochloride;Syk Inhibitor II dihydrochloride, 10 mM in DMSO;2-(2-aminoethylamino)-4-[3-(trifluoromethyl)anilino]pyrimidine-5-carboxamide,dihydrate,dihydrochloride | | CAS: | 227449-73-2 | | MF: | C14H16ClF3N6O | | MW: | 376.77 | | EINECS: | | | Product Categories: | | | Mol File: | 227449-73-2.mol |  |
| | Syk Inhibitor II Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 2 mg/ml; DMSO: 30 mg/ml; Ethanol: 0.3 mg/ml; PBS (pH 7.2): 10 mg/ml | | form | A crystalline solid | | color | off-white | | InChI | 1S/C14H15F3N6O.2ClH.2H2O/c15-14(16,17)8-2-1-3-9(6-8)22-12-10(11(19)24)7-21-13(23-12)20-5-4-18;;;;/h1-3,6-7H,4-5,18H2,(H2,19,24)(H2,20,21,22,23);2*1H;2*1H2 | | InChIKey | LCACSMNPIITJGG-UHFFFAOYSA-N |
| WGK Germany | WGK 1 | | Storage Class | 11 - Combustible Solids |
| | Syk Inhibitor II Usage And Synthesis |
| Uses | 2-[(2-Aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-5-pyrimidinecarboxamide Hydrochloride was identified via a small molecule screening assay. In addition, this compound inhibits tyrosine kinase and may be a useful reagent to investigate cellular signalling pathways. | | Biological Activity | Cell permeable: yes', 'Primary Target
Syk', 'Product competes with ATP.', 'Reversible: yes', 'Target IC50: 41 nM against Syk; 460 nM against FcεRI-mediated 5-HT release in RBL-2H3 cells in vitro | | in vivo | Syk Inhibitor II (Compound 9a; 10-100 mg/kg) dihydrochloride is subcutaneously administered to mice 30 min before antigen challenge. Syk Inhibitor II inhibits the anaphylaxis reaction dose-dependently with an ID50 value of 13.2 mg/kg[1]. | Animal Model: | ICR mice[1] | | Dosage: | 10, 30, 100 mg/kg | | Administration: | S.c.; 30 min before antigen challenge | | Result: | Inhibited the anaphylaxis reaction dose-dependently with an ID50 value of 13.2 mg/kg. |
| | IC 50 | 5-HT Receptor: 460 nM (IC50) |
| | Syk Inhibitor II Preparation Products And Raw materials |
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