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2-(4-(2-amino-2-oxoethoxy)-1-benzyl-2-ethyl-1H-indol-3-yl)-2-oxoacetamide

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Products Intro: Product Name:Hnps-PLA Inhibitor
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CAS:185298-58-2
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Products Intro: Product Name:2-(4-(2-amino-2-oxoethoxy)-1-benzyl-2-ethyl-1H-indol-3-yl)-2-oxoacetamide
CAS:185298-58-2
Purity:99% Package:1kg；25kg
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Products Intro: Product Name:MDK-8582（Hnps-PLA Inhibitor）
CAS:185298-58-2
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2-(4-(2-amino-2-oxoethoxy)-1-benzyl-2-ethyl-1H-indol-3-yl)-2-oxoacetamide Basic information
Product Name:2-(4-(2-amino-2-oxoethoxy)-1-benzyl-2-ethyl-1H-indol-3-yl)-2-oxoacetamide
Synonyms:2-(4-(2-amino-2-oxoethoxy)-1-benzyl-2-ethyl-1H-indol-3-yl)-2-oxoacetamide;hnps-PLA Inhibitor;MDK-8582(Hnps-PLA Inhibitor);HNPS-PLA INHIBITOR; MDK-8582; MDK 8582; MDK8582;MDK 8582;MDK8582;MDK-8582;1H-Indole-3-acetamide, 4-(2-amino-2-oxoethoxy)-2-ethyl-α-oxo-1-(phenylmethyl)-
CAS:185298-58-2
MF:C21H21N3O4
MW:379.41
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Mol File:185298-58-2.mol
2-(4-(2-amino-2-oxoethoxy)-1-benzyl-2-ethyl-1H-indol-3-yl)-2-oxoacetamide Structure
2-(4-(2-amino-2-oxoethoxy)-1-benzyl-2-ethyl-1H-indol-3-yl)-2-oxoacetamide Chemical Properties
Melting point >230 °C
Boiling point 709.0±70.0 °C(Predicted)
density 1.32±0.1 g/cm3(Predicted)
solubility DMSO: Sparingly soluble: 1-10 mg/ml
pka12.65±0.50(Predicted)
Safety Information
MSDS Information
2-(4-(2-amino-2-oxoethoxy)-1-benzyl-2-ethyl-1H-indol-3-yl)-2-oxoacetamide Usage And Synthesis
Useshnps-PLA-IN-1 (compound 5aa), a indole-3-acetamide, is a hnps-PLA2 inhibitor (IC50=0.124 μM)[1].
References[1] Draheim SE, et al. Indole inhibitors of human nonpancreatic secretory phospholipase A2. 3. Indole-3-glyoxamides. J Med Chem. 1996 Dec 20;39(26):5159-75. DOI:10.1021/jm960487f
[2] PHILIPPE BERNARD . A molecular modeling and 3D QSAR study of a large series of indole inhibitors of human non-pancreatic secretory phospholipase A2[J]. European Journal of Medicinal Chemistry, 2001, 36 1: Pages 1-19. DOI: 10.1016/s0223-5234(00)01183-1
2-(4-(2-amino-2-oxoethoxy)-1-benzyl-2-ethyl-1H-indol-3-yl)-2-oxoacetamide Preparation Products And Raw materials
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