LJI308
| 中文名称 | LJI308 |
|---|---|
| 中文同义词 | RSK抑制剂(LJI308);2,6-二氟-4-(4-吗啉苯基)吡啶-3-基)苯酚;化合物LJI308;LJI308,RSK抑制剂;化合物LJI308,10 MM DMSO 溶液 |
| 英文名称 | LJI308 |
| 英文同义词 | LJI308;LJI 308;LJI308;LJI-308;LJI 308;LJI308;CS-2181;2,6-Difluoro-4-[4-[4-(4-morpholinyl)phenyl]-3-pyridinyl]phenol;Phenol, 2,6-difluoro-4-[4-[4-(4-morpholinyl)phenyl]-3-pyridinyl]-;LJI308 >=98% (HPLC);viability,Ribosomal S6 Kinase (RSK),LJI-308,stimulation,phosphorylation,LJI308,inhibit,mutation,Inhibitor,LJI 308,breaks,double-strand,cancer,S6K |
| CAS号 | 1627709-94-7 |
| 分子式 | C21H18F2N2O2 |
| 分子量 | 368.38 |
| EINECS号 | 604-604-1 |
| 相关类别 | 细胞生物学试剂;抑制剂 |
| Mol文件 | 1627709-94-7.mol |
| 结构式 |  |
LJI308 性质
| 储存条件 | Inert atmosphere,Store in freezer, under -20°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 结晶固体 |
| 颜色 | 浅黄至黄色 |
| InChI | InChI=1S/C21H18F2N2O2/c22-19-11-15(12-20(23)21(19)26)18-13-24-6-5-17(18)14-1-3-16(4-2-14)25-7-9-27-10-8-25/h1-6,11-13,26H,7-10H2 |
| InChIKey | YUYJEQHNWKQNBT-UHFFFAOYSA-N |
| SMILES | C1(O)=C(F)C=C(C2=C(C3=CC=C(N4CCOCC4)C=C3)C=CN=C2)C=C1F |
LJI308 是一种有效的泛 RSK 抑制剂，对 RSK1、RSK2 和 RSK3 的 IC50 分别为 6 nM、4 nM 和 13 nM。LJI308 抑制辐照、EGF 处理和 表达 KRAS 突变的细胞中 RSK (T359/S363) 和 YB-1 (S102) 的磷酸化。
LJI308 inhibits S6K1 with an IC
50
of 0.8 μM.
LJI308 inhibits YB-1 phosphorylation in CRC cells at concentrations of 5 to 25 μM. In a dose kinetics experiment, LJI308, starting at 2.5 μM, inhibits YB-1 phosphorylation in the KRAS mutated TNBC cell line MDA-MB-231 by approximately 86%. LJI308 effectively blocks RSK and YB-1 phosphorylation after EGF stimulation and after irradiation in KRAS wild-type HBL-100 cells.
LJI308 (1-10 μM; 96 hours) decreases cell viability by up to 90%.
Cell Viability Assay
| Cell Line: | HTRY-LT cell lines |
| Concentration: | 1-10 μM |
| Incubation Time: | 96 hours |
| Result: | Decreased cell viability by up to 90%. |
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 海关编码 | 2934999090 |
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-19713 | LJI308 | 1627709-94-7 | 1 mg | 409元 |
| 2025/12/22 | HY-19713 | LJI308 LJI308 | 1627709-94-7 | 10mM * 1mLin DMSO | 729元 |