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(R)-3-(4-(2-(4-((S)-3-chloro-2-hydroxypropoxy)phenyl)propan-2-yl)phenoxy)propane-1,2-diol

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(R)-3-(4-(2-(4-((S)-3-chloro-2-hydroxypropoxy)phenyl)propan-2-yl)phenoxy)propane-1,2-diol manufacturers

  • Ralaniten
  • Ralaniten pictures
  • $3.00
  • 2026-08-25
  • CAS:1203490-23-6
  • Min. Order: 1kg
  • Purity: 99%min
  • Supply Ability: 50kg
(R)-3-(4-(2-(4-((S)-3-chloro-2-hydroxypropoxy)phenyl)propan-2-yl)phenoxy)propane-1,2-diol Basic information
Product Name:(R)-3-(4-(2-(4-((S)-3-chloro-2-hydroxypropoxy)phenyl)propan-2-yl)phenoxy)propane-1,2-diol
Synonyms:(R)-3-(4-(2-(4-((S)-3-chloro-2-hydroxypropoxy)phenyl)propan-2-yl)phenoxy)propane-1,2-diol;1,2-Propanediol, 3-[4-[1-[4-[(2S)-3-chloro-2-hydroxypropoxy]phenyl]-1-methylethyl]phenoxy]-, (2R)-;Ralaniten, 10 mM in DMSO;(R)-3-[4-[1-[4-[(S)-3-Chloro-2-hydroxypropoxy] phenyl]-1-methylethyl]phenoxy]-1,2-propanediol;EPI002
CAS:1203490-23-6
MF:C21H27ClO5
MW:394.89
EINECS:
Product Categories:
Mol File:1203490-23-6.mol
(R)-3-(4-(2-(4-((S)-3-chloro-2-hydroxypropoxy)phenyl)propan-2-yl)phenoxy)propane-1,2-diol Structure
(R)-3-(4-(2-(4-((S)-3-chloro-2-hydroxypropoxy)phenyl)propan-2-yl)phenoxy)propane-1,2-diol Chemical Properties
Boiling point 601.0±55.0 °C(Predicted)
density 1.228±0.06 g/cm3(Predicted)
storage temp. 4°C, protect from light
solubility DMSO : 100 mg/mL (253.24 mM; Need ultrasonic)
form Solid
pka13.13±0.20(Predicted)
color White to off-white
Safety Information
MSDS Information
(R)-3-(4-(2-(4-((S)-3-chloro-2-hydroxypropoxy)phenyl)propan-2-yl)phenoxy)propane-1,2-diol Usage And Synthesis
UsesRalaniten (EPI-002) is a potent and orally active antagonist of the androgen receptor-N-terminal domain (AR-NTD). Ralaniten inhibits AR transcriptional activity, with IC50 of 7.4 μM. Ralaniten can be used for the research of castration-resistant prostate cancer (CRPC)[1][2].
in vivo

EPI-002 (100 mg/kg; p.o. twice daily for 28 days) inhibits the VCaP tumor growth in castrated mice[1].

Animal Model:Male NOD-SCID mice bearing subcutaneous tumors were castrated
Dosage:100 mg/kg
Administration:P.o. twice daily for 28 days
Result:Inhibited the growth of castration-resistant prostate cancer (CRPC) xenografts that express AR splice variants[1].
References[1] Myung JK, et, al. An androgen receptor N-terminal domain antagonist for treating prostate cancer. J Clin Invest. 2013 Jul;123(7):2948-60. DOI:10.1172/JCI66398
[2] Yang YC, et, al. Targeting Androgen Receptor Activation Function-1 with EPI to Overcome Resistance Mechanisms in Castration-Resistant Prostate Cancer. Clin Cancer Res. 2016 Sep 1;22(17):4466-77. DOI:10.1158/1078-0432.CCR-15-2901
(R)-3-(4-(2-(4-((S)-3-chloro-2-hydroxypropoxy)phenyl)propan-2-yl)phenoxy)propane-1,2-diol Preparation Products And Raw materials
Tag:(R)-3-(4-(2-(4-((S)-3-chloro-2-hydroxypropoxy)phenyl)propan-2-yl)phenoxy)propane-1,2-diol(1203490-23-6) Related Product Information
2,2',2''-[methylidynetris(p-phenyleneoxymethylene)]trioxirane Bisphenol A Bis(2,3-dihydroxypropyl) Ether Cyclo-di-BADGE 1,2-Propanediol, 3-[4-[1-(4-hydroxyphenyl)-1-methylethyl]phenoxy]- 4-[1-[4-[2-Hydroxy-3-[4-[1-methyl-1-[4-(2-oxiranylmethoxy)phenyl]ethyl]phenoxy]propoxy]phenyl]-1-methylethyl]phenol (R)-3-(4-(2-(4-((S)-3-chloro-2-hydroxypropoxy)phenyl)propan-2-yl)phenoxy)propane-1,2-diol