T5601640
| 中文名称 | T5601640 |
|---|---|
| 中文同义词 | LIMK2抑制剂(T56-LIMKI);化合物T56-LIMKI;T5601640游离态;3-甲基-N-(3-((3-(三氟甲基)苯基)氨基甲酰基)苯基)异恶唑-5-甲酰胺;T 5601640,LIMK2抑制剂;化合物T56-LIMKI,10 MM DMSO 溶液;T56-LIMKi ,S6498 |
| 英文名称 | T5601640 |
| 英文同义词 | T5601640;T56-LIMKi;3-methyl-N-[3-[[3-(trifluoromethyl)phenyl]carbamoyl]phenyl]-1,2-oxazole-5-carboxamide;T-5601640(T56-LIMKi);3-Methyl-N-[3-[[[3-(trifluoromethyl)phenyl]amino]carbonyl]phenyl]-5-isoxazolecarboxamide;T5601640;T 5601640;T56-LIMKI;T56-LIMKi - T5601640;5-Isoxazolecarboxamide, 3-methyl-N-[3-[[[3-(trifluoromethyl)phenyl]amino]carbonyl]phenyl]- |
| CAS号 | 924473-59-6 |
| 分子式 | C19H14F3N3O3 |
| 分子量 | 389.33 |
| EINECS号 | 604-604-1 |
| 相关类别 | 细胞生物学试剂 |
| Mol文件 | 924473-59-6.mol |
| 结构式 |  |
T5601640 性质
| 沸点 | 403.4±45.0 °C(Predicted) |
|---|---|
| 密度 | 1.426±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | DMF：30mg/mL； DMF:PBS(pH7.2)(1:2)：0.33mg/ml；二甲基亚砜：20mg/mL |
| 形态 | 粉末 |
| 酸度系数(pKa) | 11.41±0.70(Predicted) |
| 颜色 | 白色至米色 |
| InChI | 1S/C19H14F3N3O3/c1-11-8-16(28-25-11)18(27)24-14-6-2-4-12(9-14)17(26)23-15-7-3-5-13(10-15)19(20,21)22/h2-10H,1H3,(H,23,26)(H,24,27) |
| InChIKey | XVOKFRPKSAWELK-UHFFFAOYSA-N |
| SMILES | O=C(NC1=CC(C(F)(F)F)=CC=C1)C2=CC(NC(C3=CC(C)=NO3)=O)=CC=C2 |
| Target | Value |
|
LIMK2
() |
T56-LIMKi efficiently inhibits the growth of ST88-14, U87, Panc-1 cells, A549 lung cancer cells with IC 50 values of 18.3, 7.4, 35.2 and 90 μM, respectively. T56-LIMKi decreases phosphorylated cofilin (p-cofilin) levels and thus inhibits growth of several cancerous cell lines, including those of pancreatic cancer, glioma and schwannoma. It blocks the phosphorylation of cofilin which leads to actin severance and inhibition of tumor cell migration, tumor cell growth, and anchorage-independent colony formation in soft agar. T56-LIMKi (10-50 μM) reduces p-cofilin in a dose-dependent manner in NF1 −/− MEFs with an IC 50 of 30 μM. Notably, the inhibitor does not affect the amounts of total cofil. 50μM T56-LIMKi causes a statistically significant reduction in the number of cells exhibiting stress fibers.
T56-LIMKi can induce inhibition of cofilin phosphorylation and Panc-1 tumor shrinkage in vivo . Mice treated with T56-LIMKi (60 mg/kg) shows a significant decrease in tumor volume compared to control.
安全信息
| 危险品运输编号 | UN 2811 6.1 / PGIII |
|---|---|
| WGK Germany | WGK 3 |
| 存储类别 | 6.1C - 可燃，急性毒性 类别3 毒性化合物或者引起慢性影响的化合物 |
| 危险性类别 | 急性毒性 类别3经口 危害水生环境-长期危害 类别4 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/07/06 | S6498 | T5601640 T56-LIMKi | 924473-59-6 | 5mg | 958.41元 |
| 2026/06/05 | HY-19352 | T5601640 T56-LIMKi | 924473-59-6 | 1 mg | 233元 |