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| | 3,5-DIMETHOXYBENZYL BROMIDE Basic information | | Uses |
| Product Name: | 3,5-DIMETHOXYBENZYL BROMIDE | | Synonyms: | 3,5-DIMETHOXYBENZYL BROMIDE;ALPHA-BROMO-3,5-DIMETHOXYTOLUENE;1-(Bromomethyl)-3,5-dimethoxybenzene;3,5-DIMETHOXYBENZYLBROMID;Benzene, 1-(bromomethyl)-3,5-dimethoxy-;3,5-Dimethoxybenzylamine Bromide;5-(BroMoMethyl)-1,3-diMethoxybenzene;α-BroMo-3,5-diMethoxytoluene | | CAS: | 877-88-3 | | MF: | C9H11BrO2 | | MW: | 231.09 | | EINECS: | | | Product Categories: | C9;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds;Building Blocks;Aromatics;Miscellaneous Reagents;Ethers;Organic Building Blocks;Oxygen Compounds;Building Blocks for Dendrimers;Functional Materials;Miscellaneous | | Mol File: | 877-88-3.mol |  |
| | 3,5-DIMETHOXYBENZYL BROMIDE Chemical Properties |
| Melting point | 69-70 °C (lit.) | | Boiling point | 292.1±25.0 °C(Predicted) | | density | 1.384±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | soluble in Methanol | | form | Crystalline Powder | | color | White to brown | | InChI | InChI=1S/C9H11BrO2/c1-11-8-3-7(6-10)4-9(5-8)12-2/h3-5H,6H2,1-2H3 | | InChIKey | BTHIGJGJAPYFSJ-UHFFFAOYSA-N | | SMILES | C1(CBr)=CC(OC)=CC(OC)=C1 | | CAS DataBase Reference | 877-88-3(CAS DataBase Reference) |
| Hazard Codes | C | | Risk Statements | 34 | | Safety Statements | 26-27-36/37/39-45 | | RIDADR | UN 3261 8/PG 2 | | WGK Germany | 3 | | HazardClass | 8 | | PackingGroup | II | | HS Code | 29093090 |
| | 3,5-DIMETHOXYBENZYL BROMIDE Usage And Synthesis |
| Uses | 3,5-Dimethoxybenzyl bromide may be used in various organic synthesis such as 3,4,3′,5′-tetramethoxystilbene; 3,5-dimethoxyphenylacetic acid; 1-(3,5-dimethoxyphenyl)-4-pentene etc., and 3,5-Dimethoxybenzyl bromide may be used as starting material in the multi-step synthesis of resveratroland 3,5-dimethoxyhomophthalic acid.
| | Chemical Properties | 3,5-DIMETHOXYBENZYL BROMIDE is White Solid | | Uses | 3,5-Dimethoxybenzyl bromide may be used in the synthesis of:
- 3,4,3′,5′-tetramethoxystilbene
- 3,5-dimethoxyphenylacetic acid
- 1-(3,5-dimethoxyphenyl)-4-pentene
It may be used as starting material in the multi-step synthesis of resveratrol and 3,5-dimethoxyhomophthalic acid. | | Uses | 3,5-DIMETHOXYBENZYL BROMIDE is used in dimethoxybenzene alkyl addition. | | General Description | 3,5-Dimethoxybenzyl bromide is an aromatic bromide. | | Synthesis | General procedure for the synthesis of 3,5-dimethoxybenzyl bromide from 3,5-dimethoxybenzyl alcohol: 3,5-dimethoxybenzyl alcohol (1 mmol) was dissolved in anhydrous benzene (15 mL) under anhydrous conditions and phosphorus tribromide (0.5 mL) was added. The reaction mixture was stirred at room temperature until the reaction was complete. The target product 3,5-dimethoxybenzyl bromide was obtained in quantitative yield by conventional post-treatment. | | References | [1] Journal of Steroid Biochemistry and Molecular Biology, 2013, vol. 137, p. 332 - 344
[2] Journal of Asian Natural Products Research, 2011, vol. 13, # 4, p. 290 - 296
[3] Patent: WO2016/164703, 2016, A1. Location in patent: Page/Page column 41
[4] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 24, p. 7683 - 7687
[5] Medicinal Chemistry Research, 2016, vol. 25, # 4, p. 627 - 643 |
| | 3,5-DIMETHOXYBENZYL BROMIDE Preparation Products And Raw materials |
| Raw materials | Methanol-->Sodium borohydride-->Phosphorus tribromide-->3,5-Dimethoxybenzaldehyde-->3,5-Dimethoxybenzyl alcohol-->Benzene | | Preparation Products | 3,5-Dimethoxytoluene-->5-(Bromomethyl)benzene-1,3-diol-->(3,5-DIMETHOXYBENZYL)TRIPHENYLPHOSPHONIUM BROMIDE-->4-(3,5-DIMETHOXYPHENYL)-1-BUTENE-->Propanedioic acid, [(3,5-dimethoxyphenyl)methyl]-, diethyl ester-->3,5-DIMETHOXYPHENYLACETONITRILE |
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