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| Product Name: | DFB | | Synonyms: | DFB;1-(3-fluorophenyl)-N-[(Z)-(3-fluorophenyl)methylideneamino]methanimine;Benzaldehyde, 3-fluoro-, 2-[(3-fluorophenyl)methylene]hydrazone;3,3' Difluorobenzaldazine,3,3'Difluorobenzaldazine;1,2-Bis(3-fluorobenzylidene)hydrazine;3,3'-Difluorobenzaldazine;[(3-FLUOROPHENYL)METHYLENE]HYDRAZONE-3-FLUOROBENZALDEHYDE | | CAS: | 15332-10-2 | | MF: | C14H10F2N2 | | MW: | 244.24 | | EINECS: | | | Product Categories: | Glutamate receptor | | Mol File: | 15332-10-2.mol |  |
| Boiling point | 326.6±42.0 °C(Predicted) | | density | 1.12±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: ~12 mg/mL | | form | solid | | pka | 5.78±0.50(Predicted) | | color | yellow | | InChI | 1S/C14H10F2N2/c15-13-5-1-3-11(7-13)9-17-18-10-12-4-2-6-14(16)8-12/h1-10H/b17-9-,18-10- | | InChIKey | YYMCVDNIIFNDJK-XFQWXJFMSA-N |
| Hazard Codes | Xn,N | | Risk Statements | 22-50/53 | | Safety Statements | 60-61 | | RIDADR | UN 3077 9/PG 3 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Aquatic Acute 1 |
| Uses | DFB is an allosteric potentiator of mGluR-5. | | Definition | ChEBI: Bis(3-fluorobenzylidene)hydrazine is an azine and a member of monofluorobenzenes. | | Biological Activity | Novel allosteric potentiator of the metabotropic glutamate receptor mGlu 5 . Devoid of agonist activity itself, but potentiates (3-6-fold) the action of agonists at mGlu 5 without any effect at other mGlu subtypes (EC 50 for potentiation = 2-5.3 μ M). | | in vivo | 3,3'-Difluorobenzaldazine (40-100 nmol; icv) attenuates the locomotor hyperactivity, motor incoordination, and cognitive impairment induced by Ketamine[2]. | Animal Model: | Male NMRI and ICR mice (8-9 weeks, 33-40 g)[2] | | Dosage: | 40-100 nmol (~9.7-24.4 μg) | | Administration: | ICV | | Result: | Attenuated the locomotor hyperactivity, motor incoordination, and cognitive impairment induced by Ketamine.
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| | DFB Preparation Products And Raw materials |
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