VU-29 manufacturers
- VU-29
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- $29.00
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2026-04-22
- CAS:890764-36-0
- Purity: 99.63%
- Supply Ability: 10g
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| Product Name: | VU-29 | | Synonyms: | VU-29;BenzaMide, N-(1,3-diphenyl-1H-pyrazol-5-yl)-4-nitro-;N-(1,3-Diphenyl-1H-pyrazol-5-yl)-4-nitrobenzamide;N-(1,3-Diphenyl-1H-pyrazolo-5-yl)-4-nitrobenzamide;mGluR,hippocampal,inhibit,rat,LTP,VU29,potentiator,VU-29,allosteric,Metabotropic glutamate receptors,Inhibitor,LTD;VU-29/VU29;VU-29, 10 mM in DMSO;VU-29 ，S1970 | | CAS: | 890764-36-0 | | MF: | C22H16N4O3 | | MW: | 384.39 | | EINECS: | | | Product Categories: | | | Mol File: | 890764-36-0.mol |  |
| | VU-29 Chemical Properties |
| Melting point | 221-223℃ | | Boiling point | 545.0±45.0 °C(Predicted) | | density | 1.30 | | storage temp. | Store at RT | | solubility | Soluble to 100 mM in DMSO | | form | Powder | | pka | 11.17±0.70(Predicted) | | color | Light yellow to yellow |
| | VU-29 Usage And Synthesis |
| Uses | DPAP is a potent, postive allosteric, potentiator at mGluR-5. | | in vivo | VU-29 (500 nM) potentiates DHPG induced increases in phosphoinositide (PI) hydrolysis in rat hippocampal slices. VU-29 potentiates threshold TBS-induced long term potentiation (LTP) in rat hippocampal CA1 region. VU-29 (1 μM) potentiates chemically induced mGluR-long term depression (LTD) in area CA1 of the rat hippocampus. VU-29 (1 μM) potentiates stimulus-induced NMDA receptor-independent LTD[1]. | | IC 50 | rat mGluR5: 9 nM (EC50); rat mGluR1: 557 nM (EC50); rat mGluR2: 1.5 μM (EC50); hmGluR4: 154 nM (EC50); rat mGluR5: 224 nM (Ki) |
| | VU-29 Preparation Products And Raw materials |
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