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| | Z-Ala-Ala-Asn-AMC Basic information |
| Product Name: | Z-Ala-Ala-Asn-AMC | | Synonyms: | BENZYLOXYCARBONYL-L-ALANYL-L-ALANYL-L-ASPARAGINE 4-METHYLCOUMARYL-7-AMIDE;Z-AAN-AMC;Z-ALA-ALA-ASN-MCA;L-Aspartamide, N-[(phenylmethoxy)carbonyl]-L-alanyl-L-alanyl-N1-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-;Benzyl ((S)-1-(((S)-1-(((S)-4-amino-1-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-1,4-dioxobutan-2-yl)amino)-1-oxopropan-2-yl)amino)-1-oxopropan-2-yl)carbamate;Z-Ala-Ala-Asn-AMC | | CAS: | 149697-16-5 | | MF: | C28H31N5O8 | | MW: | 565.57 | | EINECS: | | | Product Categories: | peptide | | Mol File: | 149697-16-5.mol |  |
| | Z-Ala-Ala-Asn-AMC Chemical Properties |
| Boiling point | 984.1±65.0 °C(Predicted) | | density | 1.346±0.06 g/cm3(Predicted) | | storage temp. | -15°C | | solubility | Soluble in DMSO | | pka | 11.14±0.46(Predicted) | | form | Solid | | color | White to off-white |
| | Z-Ala-Ala-Asn-AMC Usage And Synthesis |
| Uses | Z-Ala-Ala-Asn-AMC (Cbz-Ala-Ala-Asn-AMC) is the legumain substrate. Overexpressed legumain in 293 HEK-Leg cells potently cleaved CBZ-Ala-Ala-Asn-AMC[1]. | | References | [1] Stern L, Perry R, Ofek P, Many A, Shabat D, Satchi-Fainaro R. A novel antitumor prodrug platform designed to be cleaved by the endoprotease legumain. Bioconjug Chem. 2009;20(3):500-510. DOI:10.1021/bc800448u
[2] James C. Powers, et al. Propenoyl hydrazides. US7482379B2.
[3] Poreba M, et al. Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes. Cell Chem Biol. 2016;23(8):1023-1035. DOI:10.1016/j.chembiol.2016.05.020 |
| | Z-Ala-Ala-Asn-AMC Preparation Products And Raw materials |
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