VU 0409551

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Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:JNJ-46778212；VU 0409551
CAS:1363281-27-9
Purity:98.00% Package:10 mg；100 mg；2 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Zhejiang J&C Biological Technology Co.,Limited
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Products Intro: Product Name:JNJ-46778212
CAS:1363281-27-9
Purity:99% Package:5KG;1KG Remarks:JNJ-46778212
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:JNJ-46778212
CAS:1363281-27-9
Purity:98% Package:5mg Remarks:V4511
Company Name: Nantong HI-FUTURE Biology Co., Ltd.
Tel: +undefined18051384581
Email: sales@chemhifuture.com
Products Intro: Product Name:VU 0409551
CAS:1363281-27-9
Purity:0.98 Package:5mg，10mg，100mg，500mg，1g，5g，10g
Company Name: Zibo Hangyu Biotechnology Development Co., Ltd
Tel: +86-0533-2185556 +8615965530500
Email: nickzhang@hangyubiotech.com
Products Intro: Product Name:JNJ-46778212
CAS:1363281-27-9
VU 0409551 Basic information
Product Name:VU 0409551
Synonyms:VU 0409551;JNJ-46778212;[6,7-Dihydro-2-(phenoxymethyl)oxazolo[5,4-c]pyridin-5(4H)-yl](fluorophenyl)methanone;(4-fluorophenyl)-[2-(phenoxymethyl)-6,7-dihydro-4H-oxazolo[5,4-c]pyridin-5-yl]methanone;Methanone, [6,7-dihydro-2-(phenoxymethyl)oxazolo[5,4-c]pyridin-5(4H)-yl](4-fluorophenyl)-;JNJ 46778212,JNJ46778212;(4-Fluorophenyl)(2-(phenoxymethyl)-6,7-dihydrooxazolo[5,4-c]pyridin-5(4H)-yl)methanone;JNJ-46778212, 10 mM in DMSO
CAS:1363281-27-9
MF:C20H17FN2O3
MW:352.36
EINECS:
Product Categories:
Mol File:1363281-27-9.mol
VU 0409551 Structure
VU 0409551 Chemical Properties
Boiling point 545.8±50.0 °C(Predicted)
density 1.308±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: soluble; Ethanol: soluble
form A crystalline solid
pka1.35±0.20(Predicted)
color Light yellow to yellow
InChIKeyQUZLMKNNIUSREV-UHFFFAOYSA-N
SMILESO=C(N1CCC2=C(C1)OC(COC3=CC=CC=C3)=N2)C4=CC=C(C=C4)F
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
MSDS Information
VU 0409551 Usage And Synthesis
UsesVU 0409551 is an mGlu5 allosteric modulator.
Biological ActivityVU0409551 (JNJ-46778212) is an orally available, potent and selective biased metabotropic glutamate receptor subtype 5 positive allosteric modulator (mGlu5 PAM). VU0409551 (JNJ-46778212) selectively potentiates mGlu5 coupling to Gaq-mediated signaling without modulation of NMDAR currents in hippocampal neurons. VU0409551 exhibits potent antipsychotic-like and cognition enhancing activity in animal models.
in vivo

In oral brain/plasma studies, JNJ-46778212 displays excellent CNS penetration[1]. JNJ-46778212 enhances NMDAR function and rescues long-term potentiation in hippocampal slices obtained from SR/ mice. The administration of JNJ-46778212 to SR/ mice reverses their deficits in several neuroplasticity signaling pathways and improves their contextual fear memory[2].

IC 50mGlu5 Receptor: 260 nM (EC50)
storageStore at +4°C
VU 0409551 Preparation Products And Raw materials
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