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5-(1,1-Dimethylheptyl)-2-[5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]phenol manufacturers
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| | 5-(1,1-Dimethylheptyl)-2-[5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]phenol Basic information |
| Product Name: | 5-(1,1-Dimethylheptyl)-2-[5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]phenol | | Synonyms: | CP 55,940;(-)-CIS-3-[2-HYDROXY-4-(1,1-DIMETHYLHEPTYL)PHENYL]-TRANS-4-(3-HYDROXYPHENYL) CYCLOHEXANOL;(-)-CIS-3-[2-HYDROXY-4-(1,1-DIMETHYLHEPTYL)PHENYL]-TRANS-4-(3-HYDROXYPROPYL)CYCLOHEXANOL;(-)-Cis-3-[2-Hydroxy-4-(1,1-Di;(1R)-3β-[2-Hydroxy-4-(1,1-dimethylheptyl)phenyl]-4α-(3-hydroxypropyl)cyclohexane-1β-ol;3β-[4-(1,1-Dimethylheptyl)-2-hydroxyphenyl]-4α-(3-hydroxypropyl)cyclohexan-1β-ol;5-(1,1-DIMETHYLHEPTYL)-2-[(1R,2R,5R)-5-HYDROXY-2-(3-HYDROXYPROPYL)CYCLOHEXYL]PHENOL;2-[5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-Methyloctan-2-yl)phenol | | CAS: | 83002-04-4 | | MF: | C24H40O3 | | MW: | 376.57 | | EINECS: | | | Product Categories: | Cannabinoid receptor;Aromatics;Chiral Reagents;Intermediates & Fine Chemicals;Pfizer Compounds;Pharmaceuticals | | Mol File: | 83002-04-4.mol | ![5-(1,1-Dimethylheptyl)-2-[5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]phenol Structure](CAS/GIF/83002-04-4.gif) |
| | 5-(1,1-Dimethylheptyl)-2-[5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]phenol Chemical Properties |
| Melting point | 65-68 °C | | Boiling point | 494.4±45.0 °C(Predicted) | | density | 1.026±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: 15 mg/mL, soluble | | pka | 10.25±0.40(Predicted) | | form | solid | | Optical Rotation | [α]/D -24 to -30°, c =0.2 in chloroform-d | | InChI | 1S/C24H40O3/c1-4-5-6-7-14-24(2,3)19-11-13-21(23(27)16-19)22-17-20(26)12-10-18(22)9-8-15-25/h11,13,16,18,20,22,25-27H,4-10,12,14-15,17H2,1-3H3/t18-,20-,22-/m1/s1 | | InChIKey | YNZFFALZMRAPHQ-SYYKKAFVSA-N | | SMILES | CCCCCCC(C)(C)c1ccc([C@@H]2C[C@H](O)CC[C@H]2CCCO)c(O)c1 |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | STOT SE 3 |
| | 5-(1,1-Dimethylheptyl)-2-[5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]phenol Usage And Synthesis |
| Uses | CP 55,940 is a cannabinoid agonist which is considerably more potent than Δ9-THC in both behavioral tests and receptor binding assays. Displays high and roughly equal affinity for both central and peripheral cannabinoid receptors (Ki = 0.6 - 5.0 and 0.7 - 2.6 nM at CB1 and CB2 respectively; EC50 values are 0.2, 0.3 and 5 nM at CB1, CB2 and GRP55 respectively).
Controlled substance. | | Uses | (+)-CP 55940 is the enantiomer of (C781415), a cannabinoid agonist. Both CP 55,940 and (+)-CP 55940 bind to CB receptors but only CP-55,940 elicits a biological response via the receptors. However, (
+)-CP 55940 shows the same antinociceptive effects as its enantiomer. | | Uses | CP-55940 has been used as a cannabinoid agonists in Chinese hamster ovary (CHO) expressing cannabinoid receptor 2(CB2). | | Definition | ChEBI: 2-[5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol is an alkylbenzene and a ring assembly. | | Biological Activity | Cannabinoid agonist which is considerably more potent than Δ 9 -THC in both behavioral tests and receptor binding assays. Displays high and roughly equal affinity for both central and peripheral cannabinoid receptors (K i = 0.6-5.0 and 0.7-2.6 nM at CB 1 and CB 2 respectively; EC 50 values are 0.2, 0.3 and 5 nM at CB 1 , CB 2 and GRP55 respectively). Also available as part of the Cannabinoid Receptor Agonist Tocriset™ . | | Biochem/physiol Actions | CP-55940 is a nonclassical cannabinoids (NCCs), which lack the tetrahydropyran ring. CP-55940, a derivative of CP-47,497 is enantioselective. Due to its amphipathic nature, CP-55940 tethers in biological membrane making it favourable for the cannabinoid receptor interaction. CP-55940 belongs to the cyclohexylphenol category and modulates the brain lipidome leading to dysregulation especially during adolescence. It inhibits capsaicin-evoked sensitization of nociceptive and spinal dorsal horn neurons. |
| | 5-(1,1-Dimethylheptyl)-2-[5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]phenol Preparation Products And Raw materials |
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