1-Boc-2-methyl-piperidin-4-one

1-Boc-2-methyl-piperidin-4-one Suppliers list

Company Name:	Aikon International Limited Gold
Tel:	17714375163
Email:	hywu@aikonchem.com

Company Name:	Wuhan Chemwish Technology Co., Ltd
Tel:	86-027-67849912
Email:	sales@chemwish.com

1-Boc-2-methyl-piperidin-4-one manufacturers

1-Boc-2-methyl-piperidin-4-one Basic information

Product Name:	1-Boc-2-methyl-piperidin-4-one
Synonyms:	2-METHYL-4-OXOPIPERIDINE, N-BOC PROTECTED;1-N-BOC-2-METHYL-PIPERIDIN-4-ONE;1-TERT-BUTOXYCARBONYL-2-METHYL-4-PIPERIDONE;1-Boc-2-methyl-4-piperidinone;1-Boc-2-Methyl-Piperidinone;2-Methyl-4-oxopiperidine, N-BOC protected 97%;N-Boc-2-methyl-piperidone;1-(tert-Butoxycarbonyl)-2-methylpiperidin-4-one
CAS:	190906-92-4
MF:	C11H19NO3
MW:	213.27
EINECS:
Product Categories:	Pyrans, Piperidines & Piperazines;pharmacetical;Pyrans, Piperidines &Piperazines;Piperidine;Piperidines
Mol File:	190906-92-4.mol

1-Boc-2-methyl-piperidin-4-one Chemical Properties

Boiling point	298.8±33.0 °C(Predicted)
density	1.060±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	-1.52±0.40(Predicted)
form	solid
color	White to light yellow
InChI	InChI=1S/C11H19NO3/c1-8-7-9(13)5-6-12(8)10(14)15-11(2,3)4/h8H,5-7H2,1-4H3
InChIKey	HQMYWQCBINPHBB-UHFFFAOYSA-N
SMILES	N1(C(OC(C)(C)C)=O)CCC(=O)CC1C
CAS DataBase Reference	190906-92-4(CAS DataBase Reference)

Safety Information

MSDS Information

1-Boc-2-methyl-piperidin-4-one Usage And Synthesis

Uses	1-Boc-2-methyl-piperidin-4-one s a crucial compound that could be used as a pharmaceutical intermediate in pharmaceutical synthesis and scientific research.
Synthesis	126503-08-0 190906-92-4 1-tert-butoxycarbonyl-2-methyl-4-piperidone vinyl acetal (6.00 g) was used as starting material and dissolved in acetone (150 mL). To this solution, p-toluenesulfonic acid monohydrate (4.40 g) was slowly added under ice bath cooling and stirring conditions. After addition, the reaction mixture was gradually warmed to room temperature with continuous stirring overnight. Upon completion of the reaction, the reaction mixture was diluted with ethyl acetate and the organic layer was subsequently washed with saturated sodium bicarbonate solution and saturated aqueous sodium chloride solution sequentially. The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent to afford 1-tert-butoxycarbonyl-2-methyl-piperidone (2.40 g, 48% yield) as a yellow oil. Its 1H NMR (500 MHz, CDCl3) data were as follows: δ 1.18 (3H, d, J=7.0 Hz), 1.49 (9H, s), 2.20-2.30 (1H, m), 2.30-2.40 (1H, m), 2.45-2.55 (1H, m), 2.65-2.70 (1H, m), 3.25-3.35 ( 1H, m), 3.90-4.05 (1H, m), 4.20-4.30 (1H, m).
References	[1] Patent: EP1375482, 2004, A1. Location in patent: Page 153

1-Boc-2-methyl-piperidin-4-one Preparation Products And Raw materials

Raw materials	1-Cbz-2-methyl-piperidin-4-one-->4-Methoxypyridine-->1,4-Dioxa-8-azaspiro[4.5]decane-8-carboxylic acid, 7-Methyl-, 1,1-diMethylethyl ester-->2-methylpiperidin-4-one, acetic acid-->Potassium tert-butoxide-->Di-tert-butyl dicarbonate-->Methylmagnesium chloride-->p-Toluenesulfonic acid monohydrate-->Acetone
Preparation Products	tert-butyl 4,4-difluoropiperidine-1-carboxylate-->4-Amino-1-Boc-2-methylpiperidine

Tag:1-Boc-2-methyl-piperidin-4-one(190906-92-4) Related Product Information

1-Boc-2-benzyl-piperidin-4-one 1-Boc-2-phenyl-piperidin-4-one N-Boc-Nortropinone 1-Boc-2-methyl-piperidin-4-one 2-Methyl-4-piperidone 1-Boc-3-methyl-piperidin-4-one tert-butyl 8-oxo-5-azaspiro[3.5]nonane-5-carboxylate 1-Piperidinecarboxylicacid,2-methyl-4-oxo-,1,1-dimethylethylester,(2R)-(9CI) 1-Piperidinecarboxylicacid,2-methyl-4-oxo-,1,1-dimethylethylester,(2S)-(9CI) tert-Butyl 5-oxo-2-azabicyclo[2.2.1]heptane-2-carboxylate tert-Butyl 4-oxo-1-azaspiro[5.5]undecane-1-carboxylate 1-Boc-2-ethyl-piperidin-4-one tert-Butyl (2S)-2-benzyl-4-oxopiperidine-1-carboxylate tert-Butyl (2R)-2-benzyl-4-oxopiperidine-1-carboxylate 1-Boc-2-tert-butyl-piperidin-4-one 1-Boc-2-isopropyl-piperidin-4-one 1-Boc-2-propyl-piperidin-4-one (2S)-N-Boc-4-oxopipecolic acid