- Rilmenidine phosphate
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- $1.00
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2019-10-30
- CAS:85409-38-7
- Min. Order: 25Kg/Drum
- Purity: 99.00%
- Supply Ability: 1ton
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| | Rilmenidine phosphate Basic information |
| Product Name: | Rilmenidine phosphate | | Synonyms: | N-(dicyclopropylmethyl)-4,5-dihydro-2-oxazolamine,phosphate (1:1);n-(dicyclopropylmethyl)-4,5-dihydro-2-oxazolamine phosphate;Rilmenidine phosphate form;N-(Dicyclopropylmethyl)-4,5-dihydrooxazol-2-amine phosphate;rilmenidine phosphate;RILMENIDINE DIHYDROGEN PHOSPHATE;(dicyclopropylmethyl)(4,5-dihydro-2-oxazolyl)ammonium dihydrogen phosphate;dicyclopropylmethyl(4,5-dihydrooxazol-2-yl)amine | | CAS: | 85409-38-7 | | MF: | C10H19N2O5P | | MW: | 278.24 | | EINECS: | 287-106-2 | | Product Categories: | APIs;API;Antibiotics;Inhibitors;85409-38-7 | | Mol File: | 85409-38-7.mol |  |
| | Rilmenidine phosphate Chemical Properties |
| storage temp. | 2-8°C | | solubility | Freely soluble in water, slightly soluble in alcohol, practically insoluble in methylene chloride. | | form | Solid | | color | White to off-white | | Major Application | pharmaceutical (small molecule) | | InChI | 1S/C10H16N2O.H3O4P/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10;1-5(2,3)4/h7-9H,1-6H2,(H,11,12);(H3,1,2,3,4) | | InChIKey | ZJCOWRFWZOAVFY-UHFFFAOYSA-N | | SMILES | [P](=O)([O-])(O)O.[N+H2](C(C3CC3)C2CC2)C1=NCCO1 |
| WGK Germany | WGK 3 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral |
| | Rilmenidine phosphate Usage And Synthesis |
| Chemical Properties | White or almost white powder. | | Uses | Rilmenidine Phosphate is an Imidazoline I1-receptor agonist used in the treatment of hypertension. | | Uses | Antihypertensive | | Synthesis | In a 1L reaction flask equipped with mechanical stirring, thermometer and reflux condenser, 53.0g (0.46mol) of 2-ethoxyoxazoline, 56.0g (0.50mol) of bicyclopropylmethylamine and 200mL of toluene were added sequentially, stirred thoroughly, then the temperature was raised to reflux and the reaction was kept at reflux for 8h. At the end of the reaction, the temperature was lowered to 25, to which 5% sodium bicarbonate solution was added. 200 mL was washed, stratification, the organic phase was then washed with 200 mL saturated saline and 200 mL water in turn, anhydrous sodium sulfate drying, filtration, concentration to 76.2 g of the crude product, the crude product was then recrystallized with cyclohexane to obtain 75.0 g of white solid, content of 99.7%, m.p. 105.5~107 , yield 90.5%. Rilmenidine phosphate was prepared by salting rilmenidine with phosphoric acid. |
| | Rilmenidine phosphate Preparation Products And Raw materials |
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