PYRIDINE-2-THIOAMIDE manufacturers
- PYRIDINE-2-THIOAMIDE
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- $1.10 / 1g
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2025-11-18
- CAS:5346-38-3
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons Min
- PYRIDINE-2-THIOAMIDE
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- $1.00 / 1KG
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2019-07-12
- CAS:5346-38-3
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 1ton
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| | PYRIDINE-2-THIOAMIDE Basic information |
| | PYRIDINE-2-THIOAMIDE Chemical Properties |
| Melting point | 134-138 °C | | Boiling point | 278.9±32.0 °C(Predicted) | | density | 1.265±0.06 g/cm3(Predicted) | | Fp | 160 °C | | storage temp. | Inert atmosphere,Room Temperature | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml; Ethanol: 10 mg/ml | | pka | 11.98±0.29(Predicted) | | form | Crystalline Powder | | color | Yellow | | InChI | InChI=1S/C6H6N2S/c7-6(9)5-3-1-2-4-8-5/h1-4H,(H2,7,9) | | InChIKey | HYKQYVSNFPWGKQ-UHFFFAOYSA-N | | SMILES | C1(C(N)=S)=NC=CC=C1 | | CAS DataBase Reference | 5346-38-3(CAS DataBase Reference) |
| Hazard Codes | Xn | | Risk Statements | 20/21/22-36/37/38-43-41-37/38-22 | | Safety Statements | 26-36/37/39 | | WGK Germany | 3 | | RTECS | TJ4305500 | | HazardClass | IRRITANT | | HS Code | 29333999 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
Skin Sens. 1
STOT SE 3 |
| | PYRIDINE-2-THIOAMIDE Usage And Synthesis |
| Uses | 2-Pyridinecarbothioamide is a building block, that can be used for synthesis of Zn2+ responsive fluorescent probe[1]. | | Synthesis | General Steps:
a. Diphosphorus tetrasulfide (115 g, 0.5 mol) was slowly added to 250 mL of 20% ammonia in methanol solution containing 4-cyanopyridine (52 g, 0.5 mol) under vigorous stirring, ensuring that the temperature of the reaction mixture was maintained below 35-40°C. b. The reaction mixture was allowed to run for 12 hours at room temperature. The reaction mixture was stirred at room temperature for 12 hours. Upon completion of the reaction, 150 mL of water was added and the mixture was heated to 70-75 °C via a water bath until gas release ceased. After cooling to room temperature, the precipitate was collected by filtration, washed well with water and then dried. The product pyridine-2-carboxy sulfate amine was obtained in 89% yield (61.8 g) with an Rf value of 0.45 and a melting point of 137 °C (literature value: 136-137 °C). Elemental analysis result (%): C 52.09, H 4.31, N 20.30, S 23.30; theoretical value (C6H6N2S): C 52.15, H 4.38, N 20.27, S 23.20. | | References | [1] Watanabe Y, et al. A zinc-responsive fluorophore based on 5′-(p-hydroxyphenyl)-pyridylthiazole[J]. Materials Chemistry Frontiers, 2020, 4(3): 899-904. |
| | PYRIDINE-2-THIOAMIDE Preparation Products And Raw materials |
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