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| | CYN 154806 Basic information |
| Product Name: | CYN 154806 | | Synonyms: | CYN 154806;CYANAMID 154806;AC-(4-NITRO)PHE-D-CYS-TYR-D-TRP-LYS-THR-CYS-D-TYR-NH2;CYN 154806 TRIFLUOROACETATE SALT;CYANAMID 154806 trifluoroacetate salt;M.W. 1197.35 C56H68N12O14S2;CYN 154806; CYN154806;D-Tyrosinamide, N-acetyl-4-nitro-L-phenylalanyl-D-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-, cyclic (2→7)-disulfide | | CAS: | 183658-72-2 | | MF: | C56H68N12O14S2 | | MW: | 1197.34 | | EINECS: | | | Product Categories: | Somatostatin receptor | | Mol File: | 183658-72-2.mol |  |
| | CYN 154806 Chemical Properties |
| Boiling point | 1656.2±65.0 °C(Predicted) | | density | 1.47±0.1 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | DMF: 25 mg/ml
DMSO: 10 mg/ml
Ethanol: 25 mg/ml | | pka | 9.87±0.15(Predicted) | | form | powder | | color | white to off-white | | Water Solubility | Soluble to 1 mg/ml in water | | Sequence | Ac-{L-4-NO2-Phe}{D-CYS}-Tyr-{D-TRP}-Lys-Thr-Cys{D-TYR}-NH2 (Disulfidebridge:Cys2-Cys7) | | InChIKey | FYVCFCQFOBEWIO-GVGJFGMUSA-N |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | CYN 154806 Usage And Synthesis |
| Description | CYN 154806 is a cyclic peptide somatostatin receptor 2 (SST2) antagonist (IC50 = 2.62 nM).1 It is selective for SST2 over SST1, SST3, SST4, and SST5 (IC50s = 3,890, 851, 1,737, and 331 nM, respectively). CYN 154806 inhibits SST-induced increases in extracellular acidification (EAR) in CHO-K1 cells expressing recombinant human SST2 (pKB = 7.92) and [35S]GTPγS binding in CHO-K1 cell membranes expressing recombinant human SST2 (pKB = 7.81).WARNING This product is not for human or veterinary use. | | Biochem/physiol Actions | Potent and selective sst2 somatostatin receptor antagonist. | | storage | Store at -20°C | | References | [1] W FENIUK. Selective somatostatin sst2 receptor blockade with the novel cyclic octapeptide, CYN-154806[J]. Neuropharmacology, 2000, 39 8: Pages 1443-1450. DOI: 10.1016/s0028-3908(00)00035-6 |
| | CYN 154806 Preparation Products And Raw materials |
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