乙基氢化铜蛋白
| 中文名称 | 乙基氢化铜蛋白 |
|---|---|
| 中文同义词 | 乙基氢化铜蛋白,盐酸奥普托欣;奥普托欣;乙基氢化铜蛋白,97%;乙氢去甲奎宁盐酸盐;乙基氢化古铜色碱盐酸盐;乙基氢化铜蛋白;盐酸奥普托欣;盐酸乙基氢化叩卜林 |
| 英文名称 | ETHYLHYDROCUPREINE HYDROCHLORIDE |
| 英文同义词 | OPTICHIN HYDROCHLORIDE;ETHYLHYDROCUPREINE HYDROCHLORIDE;hydrocupreine,ethylester,hydrochloride;Ethylhydrocupreine HCl,Optochin HCl;neumolisina;numoquinhydrochloride;o-ethyl-hydrocupreinhydrochloride;optochinhydrochloride |
| CAS号 | 3413-58-9 |
| 分子式 | C21H29ClN2O2 |
| 分子量 | 376.92 |
| EINECS号 | 222-302-3 |
| 相关类别 | 医药中间体;乙基氢化铜蛋白;Miscellaneous |
| Mol文件 | 3413-58-9.mol |
| 结构式 |  |
乙基氢化铜蛋白 性质
| 熔点 | 121-123°C |
|---|---|
| 比旋光度 | D21 -123.6° (water) |
| 储存条件 | 2-8°C |
| 溶解度 | DMSO：125 mg/mL（331.64 mM；需要超声波） |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
| 敏感性 | Light Sensitive |
| BRN | 4055970 |
| 主要应用 | forensics and toxicology pharmaceutical (small molecule) veterinary |
| InChIKey | QNRATNLHPGXHMA-XZHTYLCXSA-N |
| SMILES | Cl[H].[H][C@@]12CCN(C[C@@H]1CC)[C@@]([H])(C2)[C@H](O)c3ccnc4ccc(OCC)cc34 |
S. pneumoniae
IC50: 25.75 nM (
Plasmodium falciparum
)
ggTas2r1,
ggTas2r2 and ggTas2r7
The mutation rate to Ethylhydrocupreine (Optochin) resistance is estimated using fluctuation analysis in three capsulated S. pneumoniae strains ( S. pneumoniae D39 NCTC 7466, S. pneumoniae R6 ATCC BAA-255 and S. pneumoniae ATCC 49619). The exposure to subinhibitory concentrations of penicillin increased the mutation rate (expressed as mutation per cell division) to Ethylhydrocupreine (Optochin) resistance between 2.1- and 3.1-fold for all three strains studied.
The injection of 1 cc. of a 24 hour dextrose blood broth culture of virulent Type I pneumococci into the right pleural cavity of guinea pigs produces acute suppurative pleuritis on both sides associated with suppurative pericarditis. The injection of 1 cc. of 1:500 solutions of Ethylhydrocupreine hydrochloride into each pleural cavity of guinea pigs at varying intervals up to 24 hours after pleural infection has usually shown a marked curative influence. Similar results are observed with dogs.
安全信息
| 危险品标志 | Xi |
|---|---|
| 危险类别码 | 36/37/38 |
| 安全说明 | 22-24/25-36-26 |
| WGK Germany | 3 |
| RTECS号 | MW6300000 |
| F | 8 |
| 海关编码 | 29392900 |
| 存储类别 | 11 - 可燃固体 |
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