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| | 3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-ol 5,5-dioxide Basic information |
| Product Name: | 3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-ol 5,5-dioxide | | Synonyms: | 3-CHLORO-6,11-DIHYDRO-5,5-DIOXO-11-HYDROXY-6-METHYLDIBENZO[C,F][1,2]THIAZEPINE;3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-ol 5,5-dioxide;3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-ol;3-Chloro-11-hydroxy-6-methyl-6,11-dihydrodibenzo[c,f][1,2]thiazepine 5,5-dioxide;3-chloro-6-methyl-5,5-dioxo-11H-benzo[c][2,1]benzothiazepin-11-ol;3-Chloro-6,11-dihydro-6-methyl-11-hydroxydibenzo[c,f][1,2]thiazepine 5,5-dioxide;Dibenzo[c,f][1,2]thiazepin-11-ol, 3-chloro-6,11-dihydro-6-methyl-, 5,5-dioxide;3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-... | | CAS: | 26723-60-4 | | MF: | C14H12ClNO3S | | MW: | 309.77 | | EINECS: | 247-944-1 | | Product Categories: | | | Mol File: | 26723-60-4.mol | ![3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-ol 5,5-dioxide Structure](CAS/GIF/26723-60-4.gif) |
| | 3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-ol 5,5-dioxide Chemical Properties |
| Melting point | 196-198°C | | Boiling point | 482.8±55.0 °C(Predicted) | | density | 1.472±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | 12.60±0.20(Predicted) | | color | White | | Water Solubility | 30mg/L at 25℃ | | LogP | 2.78 |
| | 3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-ol 5,5-dioxide Usage And Synthesis |
| Uses | 3-Chloro-6,11-dihydro-5,5-dioxo-11-hydroxy-6-methyldibenzo[c,f][1,2]thiazepine, can beused in the synthesis of Dibenzo[c,f][1,2]thiazepine derivatives. | | Synthesis | The general procedure for the synthesis of 3-chloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepin-11(6H)-one 5,5-dioxide from 3-chloro-6-methyl-dibenzo[c,f][1,2]thiazepin-11-ol 5,5-dioxide was as follows: to a solution of 3-chloro-6-methyl-dibenzo[c,f][1,2]thiazepin- 11(6H)-one 5,5-dioxide (62.5 g) to a solution of methanol (500 ml), sodium borohydride (15.04 g) was slowly added at 0-5 °C. The reaction mixture was stirred at 0-5 °C for 30 min, followed by continued stirring at room temperature for 30-60 min. After completion of the reaction, the solid product was collected by filtration and washed with methanol. The resulting solid was dried under constant weight to afford 3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-ol 5,5-dioxide in 90-95% yield. | | References | [1] Patent: WO2010/70667, 2010, A2. Location in patent: Page/Page column 5
[2] Journal of Medicinal Chemistry, 1992, vol. 35, # 13, p. 2481 - 2496 |
| | 3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-ol 5,5-dioxide Preparation Products And Raw materials |
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