3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide

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Products Intro:	Product Name:3,11-Dichloro-6,11-dihydro-6-methyld26638-66-4ibenzo[c,f][1,2]thiazepine 5,5-dioxide CAS:26638-66-4 Purity:99% Package:25KG;5KG;1KG

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Products Intro:	Product Name:3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide fandachem CAS:26638-66-4 Purity:As coa Package:As request Remarks:26638-66-4

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Products Intro:	Product Name:3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide CAS:26638-66-4 Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G

3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide manufacturers

3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide Basic information

Product Name:	3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide
Synonyms:	Dibenzo[c,f][1,2]thiazepine,3,11-dichloro-6,11-dihydro-6-methyl-,5,5-dioxide;3,11-DICHLORO-6,11-6-METHYLDIBENZO[C,F][1,2]THIAZEPINE5,5-DIOXIDE;5,8-DICHLORO-10-DIOXO-11-METHYL-DIBENZO[C,F][1,2]THIAZEPINE;DIBENZO[C,F][1,2]THIAZEPINE,3,11-DICHLORO-6,11-DIHYDRO-6-METHYL-,5,5-DIOXIDE (8CI,9CI);3-Chloro-6,11-dihydro-6-methyl-11-chlorodibenzo[c,f][1,2]thiazepine 5,5-dioxide;3,11-Dichloro-6,11-dihydro-6-methyl-5,5-dioxodibenzo[c,f][1,2]thiazepine;rac 3,11-Dichloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepine 5,5-Dioxide;Tianeptine InterMediate (the ninth step)
CAS:	26638-66-4
MF:	C14H11Cl2NO2S
MW:	328.21
EINECS:	247-866-8
Product Categories:	Intermediate;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;26638-66-4
Mol File:	26638-66-4.mol

3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide Chemical Properties

Melting point	>233oC (dec.)
Boiling point	445.3±55.0 °C(Predicted)
density	1.54±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO (Slightly)
form	Solid
pka	-4.11±0.40(Predicted)
color	White
InChI	InChI=1S/C14H11Cl2NO2S/c1-17-12-5-3-2-4-10(12)14(16)11-7-6-9(15)8-13(11)20(17,18)19/h2-8,14H,1H3
InChIKey	FHICZIHQHGRZLE-UHFFFAOYSA-N
SMILES	S1(=O)(=O)C2=CC(Cl)=CC=C2C(Cl)C2=CC=CC=C2N1C

Safety Information

MSDS Information

3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide Usage And Synthesis

Chemical Properties	Off-White Solid
Uses	Intermediate in the preparation of Tianeptine and respective metabolites
Synthesis	26723-60-4 26638-66-4 General procedure for the synthesis of 3,11-dichloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepin-11-ol 5,5-dioxide from 3-chloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepin 5,5-dioxide: the compound of formula III (58.0 g) was suspended in dichloromethane ( 600 ml) and cooled to 0-10°C. Hydrogen chloride gas was passed into the suspension at 0-10°C and the reaction was kept for 2-4 hours. Upon completion of the reaction, the precipitate was collected by filtration and the resulting solid was dried to constant weight to afford the target product 3,11-dichloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepine 5,5-dioxide in 90-95% yield.
References	[1] Patent: WO2010/70667, 2010, A2. Location in patent: Page/Page column 5 [2] Journal of Medicinal Chemistry, 1992, vol. 35, # 13, p. 2481 - 2496

3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide Preparation Products And Raw materials

Raw materials

Tag:3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide(26638-66-4) Related Product Information

Dihydromyrcenol 2-Chloro-5-chloromethylpyridine Tetramethylammonium hydroxide pentahydrate Zirconium dioxide Dichloromethylphenylsilane Dichlorodimethylsilane Carbon dioxide Sulfurous Acid Chlorine dioxide Rutile Quartz Thiophanate-methyl Tianeptine sodium salt Tianeptine Methyl Ester sulfur dioxide 3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide SilicaDioxide

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