- Tianeptine
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- $10.00
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2026-05-28
- CAS:26638-66-4
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 10 ton
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| | 3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide Basic information |
| Product Name: | 3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide | | Synonyms: | Dibenzo[c,f][1,2]thiazepine,3,11-dichloro-6,11-dihydro-6-methyl-,5,5-dioxide;3,11-DICHLORO-6,11-6-METHYLDIBENZO[C,F][1,2]THIAZEPINE5,5-DIOXIDE;5,8-DICHLORO-10-DIOXO-11-METHYL-DIBENZO[C,F][1,2]THIAZEPINE;DIBENZO[C,F][1,2]THIAZEPINE,3,11-DICHLORO-6,11-DIHYDRO-6-METHYL-,5,5-DIOXIDE (8CI,9CI);3-Chloro-6,11-dihydro-6-methyl-11-chlorodibenzo[c,f][1,2]thiazepine 5,5-dioxide;3,11-Dichloro-6,11-dihydro-6-methyl-5,5-dioxodibenzo[c,f][1,2]thiazepine;rac 3,11-Dichloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepine 5,5-Dioxide;Tianeptine InterMediate (the ninth step) | | CAS: | 26638-66-4 | | MF: | C14H11Cl2NO2S | | MW: | 328.21 | | EINECS: | 247-866-8 | | Product Categories: | Intermediate;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;26638-66-4 | | Mol File: | 26638-66-4.mol | ![3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide Structure](CAS/GIF/26638-66-4.gif) |
| | 3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide Chemical Properties |
| Melting point | >233oC (dec.) | | Boiling point | 445.3±55.0 °C(Predicted) | | density | 1.54±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO (Slightly) | | form | Solid | | pka | -4.11±0.40(Predicted) | | color | White | | InChI | InChI=1S/C14H11Cl2NO2S/c1-17-12-5-3-2-4-10(12)14(16)11-7-6-9(15)8-13(11)20(17,18)19/h2-8,14H,1H3 | | InChIKey | FHICZIHQHGRZLE-UHFFFAOYSA-N | | SMILES | S1(=O)(=O)C2=CC(Cl)=CC=C2C(Cl)C2=CC=CC=C2N1C |
| | 3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide Usage And Synthesis |
| Chemical Properties | Off-White Solid | | Uses | Intermediate in the preparation of Tianeptine and respective metabolites | | Synthesis | General procedure for the synthesis of 3,11-dichloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepin-11-ol 5,5-dioxide from 3-chloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepin 5,5-dioxide: the compound of formula III (58.0 g) was suspended in dichloromethane ( 600 ml) and cooled to 0-10°C. Hydrogen chloride gas was passed into the suspension at 0-10°C and the reaction was kept for 2-4 hours. Upon completion of the reaction, the precipitate was collected by filtration and the resulting solid was dried to constant weight to afford the target product 3,11-dichloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepine 5,5-dioxide in 90-95% yield. | | References | [1] Patent: WO2010/70667, 2010, A2. Location in patent: Page/Page column 5
[2] Journal of Medicinal Chemistry, 1992, vol. 35, # 13, p. 2481 - 2496 |
| | 3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide Preparation Products And Raw materials |
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