[5-oxido-4-(thiophene-2-carbonyl)-1,2,5-oxadiazol-5-ium-3-yl]-thiophen-2-ylmethanone
| 中文名称 | [5-oxido-4-(thiophene-2-carbonyl)-1,2,5-oxadiazol-5-ium-3-yl]-thiophen-2-ylmethanone |
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| 中文同义词 | 化合物HC-056456;化合物HC-056456,10 MM DMSO 溶液;3,4-二(噻吩-2-羰基)-1,2,5-恶二唑 2-氧化物 |
| 英文名称 | [5-oxido-4-(thiophene-2-carbonyl)-1,2,5-oxadiazol-5-ium-3-yl]-thiophen-2-ylmethanone |
| 英文同义词 | [5-oxido-4-(thiophene-2-carbonyl)-1,2,5-oxadiazol-5-ium-3-yl]-thiophen-2-ylmethanone;HC-056456 (3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide);HC-056456 (Synonyms: 3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide);3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide;HC-056456,inhibit,HC056456,Inhibitor;Methanone, 1,1'-(2-oxido-1,2,5-oxadiazole-3,4-diyl)bis[1-(2-thienyl)-;HC-056456, 10 mM in DMSO;HC-056456 |
| CAS号 | 7733-96-2 |
| 分子式 | C12H6N2O4S2 |
| 分子量 | 306.32 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 7733-96-2.mol |
| 结构式 | ![[5-oxido-4-(thiophene-2-carbonyl)-1,2,5-oxadiazol-5-ium-3-yl]-thiophen-2-ylmethanone 结构式](CAS/20210111/GIF/7733-96-2.gif) |
[5-oxido-4-(thiophene-2-carbonyl)-1,2,5-oxadiazol-5-ium-3-yl]-thiophen-2-ylmethanone 性质
| 熔点 | 113-114 °C(Solv: heptane (142-82-5)) |
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| 沸点 | 572.1±60.0 °C(Predicted) |
| 密度 | 1.67±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO:150.0(最大浓度 mg/mL);489.7(最大浓度 mM) |
| 形态 | 固体 |
| 酸度系数(pKa) | -4.77±0.10(Predicted) |
| 颜色 | 白色至米白色 |
CatSper
HC-056456 similarly slows the rise of [Ca 2+ ] i that is evoked by alkaline depolarization and reported by fura-2. HC-056456 also selectively and reversibly decreased CatSper currents recorded from patch-clamped sperm. HC-056456 produces a pharmacological phenocopy of the CatSper-null sperm. Acute application of HC-056456 causes rapid loss of flagellar waveform asymmetry from hyperactivated sperm, indicating that continued entry of Ca 2+ through CatSper channels is required to maintain hyperactivation. HC-056456 selectively and reversibly blocks CatSper currents. The specificity and reversibility of the blockade of CatSper-dependent currents by HC-056456 is examined by using patch clamp recordings. The observed current is blocked slightly more than 50% by 20 µM HC-056456 (estimated IC 50 near 15 µM). In concept, it remains possible that CatSper channel heterogeneity explains residual HC-056456-resistant current. The action of HC-056456 on KSper channels, the other major cation channel observed in patch-clamped sperm, is also examined. Subsequent application of 50 µM HC-056456 results in partial blockade of this current. For HC-056456 action on KSper an IC 50 near 40 µM is estimated.
安全信息
| 海关编码 | 2934999090 |
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