| Company Name: |
TargetMol |
| Tel: |
400-821-0310 15002144251 |
| Email: |
xuexiang.shao@tsbiochem.com |
|
| | RU-SKI 201 Basic information |
| Product Name: | RU-SKI 201 | | Synonyms: | RU-SKI 201;Ethanone, 1-[6,7-dihydro-4-(6-methyl-2-pyridinyl)thieno[3,2-c]pyridin-5(4H)-yl]-2-[(2-methylbutyl)amino]-;2-(2-Methyl-butylamino)-1-[4-(6-methyl-pyridin-2-yl)-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]-ethanone | | CAS: | 1458031-48-5 | | MF: | C20H27N3OS | | MW: | 357.51 | | EINECS: | | | Product Categories: | | | Mol File: | 1458031-48-5.mol |  |
| | RU-SKI 201 Chemical Properties |
| Boiling point | 520.7±50.0 °C(Predicted) | | density | 1.140±0.06 g/cm3(Predicted) | | pka | 8.46±0.30(Predicted) |
| | RU-SKI 201 Usage And Synthesis |
| Uses | RUSKI-201 is a potent and specific Hedgehog acyltransferase (Hhat) inhibitor, with an IC50 of 0.20 μM. RUSKI-201 is able to block Hh signaling from Shh overexpressing cells and inhibits Hh palmitoylation. RUSKI-201 is potential Hhat chemical probe in cells and can used in studies of Hhat catalytic function[1]. | | References | [1] Ursula R Rodgers, et al. Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells. ACS Chem Biol. 2016 Dec 16;11(12):3256-3262. DOI:10.1021/acschembio.6b00896 |
| | RU-SKI 201 Preparation Products And Raw materials |
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