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Galanin (rat, mouse) (trifluoroacetate salt) manufacturers
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| | Galanin (rat, mouse) (trifluoroacetate salt) Basic information |
| | Galanin (rat, mouse) (trifluoroacetate salt) Chemical Properties |
| solubility | Water: 1 mg/ml |
| | Galanin (rat, mouse) (trifluoroacetate salt) Usage And Synthesis |
| Description | Galanin is a neuropeptide with diverse biological activities.1,2,3,4,5 It inhibits forskolin-induced cAMP production in cells expressing GAL1 or GAL3 receptors (EC50s = 31.6 and 91 nM, respectively) and stimulates inositol phosphate accumulation in cells expressing GAL2 receptors (EC50 = 173.3 nM).1 Galanin binds to and inhibits contraction of guinea pig gastric smooth muscle cells induced by carbachol (Item No. 14486; IC50s = 7.9 and 4 nM, respectively).2 In vivo, Galanin (6 nmol, i.c.v.) increases feeding behavior in rats and increases latency to hindpaw withdrawal in response to heat and mechanical stimulation in a rat model of carrageenin-induced inflammation when administered at a dose of 2 nmol injected into the nucleus accumbens.3,4 Galanin (5 μg, i.c.v.) also inhibits acetylcholine (Item No. 23829) release induced by scopolamine in the ventral hippocampus of freely moving rats.5WARNING This product is not for human or veterinary use. | | References | [1] KRISTIN WEBLING . Pharmacological stimulation of GAL1R but not GAL2R attenuates kainic acid-induced neuronal cell death in the rat hippocampus[J]. Neuropeptides, 2016, 58: Pages 83-92. DOI: 10.1016/j.npep.2015.12.009
[2] Z F GU. Interaction of galanin fragments with galanin receptors on isolated smooth muscle cells from guinea pig stomach: identification of a novel galanin receptor subtype.[J]. Journal of Pharmacology and Experimental Therapeutics, 1995, 272 1: 371-378.
[3] JACQUELINE N. CRAWLEY. Activity of centrally administered galanin fragments on stimulation of feeding behavior and on galanin receptor binding in the rat hypothalamus[J]. Journal of Neuroscience, 1990, 19 1: 3695-3700. DOI: 10.1523/jneurosci.10-11-03695.1990
[4] YANG YANG . Involvements of galanin and its receptors in antinociception in nucleus accumbens of rats with inflammatory pain[J]. Neuroscience Research, 2015, 97: Pages 20-25. DOI: 10.1016/j.neures.2015.03.006
[5] M. TABER J C. Galanin attenuates the effects of scopolamine but not exposure to a novel environment on acetylcholine release in the rat ventral hippocampus[J]. Psychobiology (Austin, Tex.), 1999, 2007 1. DOI: 10.3758/bf03332099 |
| | Galanin (rat, mouse) (trifluoroacetate salt) Preparation Products And Raw materials |
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