TT-10 manufacturers
- TT-10
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- $34.00
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2026-07-27
- CAS:2230640-94-3
- Purity: 99.76%
- Supply Ability: 10g
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| Product Name: | TT-10 | | Synonyms: | TT-10;Methanone, [4-amino-2-(2-propen-1-ylamino)-5-thiazolyl](5-fluoro-2-thienyl)-;5-(5-fluorothiophene-2-carbonyl)-N2-(prop-2-en-1-yl)-1,3-thiazole-2,4-diamine;TT-10, 10 mM in DMSO;(2-(Allylamino)-4-aminothiazol-5-yl)(5-fluorothiophen-2-yl)methanone | | CAS: | 2230640-94-3 | | MF: | C11H10FN3OS2 | | MW: | 283.35 | | EINECS: | | | Product Categories: | | | Mol File: | 2230640-94-3.mol |  |
| | TT-10 Chemical Properties |
| Boiling point | 491.6±55.0 °C(Predicted) | | density | 1.462±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: 2mg/mL, clear | | form | Solid | | pka | 2.45±0.10(Predicted) | | color | Yellow to orange | | InChI | 1S/C11H10FN3OS2/c1-2-5-14-11-15-10(13)9(18-11)8(16)6-3-4-7(12)17-6/h2-4H,1,5,13H2,(H,14,15) | | InChIKey | GVYPHJQPOHDZEI-UHFFFAOYSA-N | | SMILES | NC1=C(C(C2=CC=C(S2)F)=O)SC(NCC=C)=N1 |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | TT-10 Usage And Synthesis |
| Uses | TT-10 (TAZ-K) is an activator of YES-associated protein (YAP)-transcriptional enhancer factor domain (TEAD) activity. TT-10 can be used for the research of heart diseases accompanied by cardiomyocyte loss[1]. | | Biological Activity | TT-10 (TAZ K) is a TAZ (transcriptional coactivator with PDZ-binding motif) activator th at promotes cardiomyocytes (CMs) proliferation (fold-increase by 10 μM TT-10 over untreated control = 5.2/r at CMs/40 hrs & 2.6/human iPSC-derived CMs/48 hrs) by activating YAP (YES-associated protein)/TEAD (transcriptional enhancer factor domain) complex-mediated transcription, as well as by exerting antioxidant and antiapoptotic activity. TT-10 ameliorates myocardial infarction-induced cardiac dysfunction in mice in vivo (10 mg/kg i.p.) at least in part via enhancing clonal expansion of existing cardiomyocytes with nuclear YAP expression. | | References | [1] Masamichi Ito, et al. Characterization of a small molecule that promotes cell cycle activation of human induced pluripotent stem cell-derived cardiomyocytes. J Mol Cell Cardiol. 2019 Mar;128:90-95. DOI:10.1016/j.yjmcc.2019.01.020 |
| | TT-10 Preparation Products And Raw materials |
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