N-[[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]methyl]-2-[2-[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]ethoxy]-N-methylacetamide
| 中文名称 | N-[[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]methyl]-2-[2-[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]ethoxy]-N-methylacetamide |
|---|---|
| 中文同义词 | 化合物 T34485;化合物 SAFOTIBANT |
| 英文名称 | N-[[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]methyl]-2-[2-[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]ethoxy]-N-methylacetamide |
| 英文同义词 | N-[[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]methyl]-2-[2-[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]ethoxy]-N-methylacetamide;LF 220542;LF 22-0542;LF220542;LF-220542;LF-22-0542;LF22-0542;Acetamide, N-[[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]methyl]-2-[2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl]methylamino]ethoxy]-N-methyl- |
| CAS号 | 633698-99-4 |
| 分子式 | C25H34N4O5S |
| 分子量 | 502.62626 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 633698-99-4.mol |
| 结构式 | ![N-[[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]methyl]-2-[2-[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]ethoxy]-N-methylacetamide 结构式](CAS/20200119/GIF/633698-99-4.gif) |
N-[[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]methyl]-2-[2-[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]ethoxy]-N-methylacetamide 性质
| 沸点 | 680.4±65.0 °C(Predicted) |
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| 密度 | 1.23±0.1 g/cm3(Predicted) |
| 酸度系数(pKa) | 9.92±0.40(Predicted) |
N-[[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]methyl]-2-[2-[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]ethoxy]-N-methylacetamide 用途与合成方法
Safotibant (LF22-0542) 是激肽 B1 受体 (BKB1R) 的选择性拮抗剂，对人源和鼠源 BKB1R 的 Ki 分别为 0.35 和 6.5 nM。Safotibant 在小鼠模型中表现出镇痛和抗炎活性。