N-[[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]methyl]-2-[2-[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]ethoxy]-N-methylacetamide

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N-[[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]methyl]-2-[2-[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]ethoxy]-N-methylacetamide Suppliers list
Company Name: TargetMol Chemicals Inc.  
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Company Name: Shanghai Yifei Biotechnology Co. , Ltd.  
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Company Name: TargetMol Chemicals Inc.  
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Company Name: Guangzhou Ruidi Biotechnology Co., Ltd.  
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N-[[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]methyl]-2-[2-[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]ethoxy]-N-methylacetamide manufacturers

  • Safotibant
  • Safotibant pictures
  • $88.00
  • 2026-06-03
  • CAS:633698-99-4
  • Purity: 99.62%
  • Supply Ability: 10g
N-[[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]methyl]-2-[2-[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]ethoxy]-N-methylacetamide Basic information
Product Name:N-[[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]methyl]-2-[2-[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]ethoxy]-N-methylacetamide
Synonyms:N-[[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]methyl]-2-[2-[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]ethoxy]-N-methylacetamide;LF 220542;LF 22-0542;LF220542;LF-220542;LF-22-0542;LF22-0542;Acetamide, N-[[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]methyl]-2-[2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl]methylamino]ethoxy]-N-methyl-
CAS:633698-99-4
MF:C25H34N4O5S
MW:502.62626
EINECS:
Product Categories:
Mol File:633698-99-4.mol
N-[[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]methyl]-2-[2-[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]ethoxy]-N-methylacetamide Structure
N-[[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]methyl]-2-[2-[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]ethoxy]-N-methylacetamide Chemical Properties
Boiling point 680.4±65.0 °C(Predicted)
density 1.23±0.1 g/cm3(Predicted)
pka9.92±0.40(Predicted)
Safety Information
MSDS Information
N-[[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]methyl]-2-[2-[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]ethoxy]-N-methylacetamide Usage And Synthesis
UsesSafotibant is a reagent with pharmocological activity to inhibited retinal inflammation and oxidative stress in rat with Zanosar induced diabetes
in vivo

Safotibant (10 mg/kg, s.c., 3 times a day for 8 days) exhibits analgesic property against bone cancer-induced pain in osteolytic sarcoma xenograft C3H/HeJ mice model, without affecting disease progression[1].
Safotibant (one eye drop application, twice a day for 7 days) inhibits expressions of inflammatory mediators B1R, iNOS, IL-1β, COX-2, VEGF-R2 and HIF-1α, reverses diabetes-induced retinal inflammation and oxidative stress in streptozotocin (STZ)-diabetic Wistar rats model[2].

Animal Model:Osteolytic sarcoma xenograft C3H/HeJ mice model[1]
Dosage:10 mg/kg
Administration:s.c., 3 times a day for 8 days
Result:Decreased numbers of flinching and time spent on spontaneous guarding.
Animal Model:Streptozotocin (STZ)-diabetic Wistar rats model[2]
Dosage:One eye drop
Administration:On eyes application, twice a day for 7 days
Result:Reversed retinal vascular hyperpermeability, decreased levels of retinal leukostasis and superoxide anion in 3 retinal nuclear layers.
N-[[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]methyl]-2-[2-[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]ethoxy]-N-methylacetamide Preparation Products And Raw materials
Tag:N-[[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]methyl]-2-[2-[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]ethoxy]-N-methylacetamide(633698-99-4) Related Product Information
N-[[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]methyl]-2-[2-[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]ethoxy]-N-methylacetamide Arg-Pro-Pro-Gly-Phe-Ser-Pro-Tyr-Arg Anti-Aging Compound Library Benzoic acid, 2-(1-cyclobutyl-1H-pyrazol-4-yl)-5-[[[1-[2-fluoro-4-(trifluoromethyl)phenyl]cyclopropyl]carbonyl]amino]- Arg-Pro-Pro-Gly-Phe-Ser-Pro-Leu acetate salt Icatibant