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| | UROTENSIN II-RELATED PEPTIDE (HUMAN, MOUSE, RAT) Basic information |
| Product Name: | UROTENSIN II-RELATED PEPTIDE (HUMAN, MOUSE, RAT) | | Synonyms: | M.W. 1017.23 C49H64N10O10S2;Ala-Cys-Phe-Trp-Lys-Tyr-Cys-Val (Disulfide bridge Cys2-Cys7);UIIB (huMan, Mouse, rat), Urotensin IIB (huMan, Mouse, rat), URP (huMan, Mouse, rat);ACFWKYCV( Disulfide bridge between 2 - 7);ALA-CYS-PHE-TRP-LYS-TYR-CYS-VAL;H-ALA-CYS-PHE-TRP-LYS-TYR-CYS-VAL-OH;H-ALA-CYS-PHE-TRP-LYS-TYR-CYS-VAL-OH, (DISULFIDE BOND);UIIB (HUMAN, MOUSE, RAT) | | CAS: | 342878-90-4 | | MF: | C49H64N10O10S2 | | MW: | 1017.22 | | EINECS: | | | Product Categories: | Urotensin receptor | | Mol File: | 342878-90-4.mol |  |
| | UROTENSIN II-RELATED PEPTIDE (HUMAN, MOUSE, RAT) Chemical Properties |
| Boiling point | 1424.2±65.0 °C(Predicted) | | density | 1.39±0.1 g/cm3(Predicted) | | storage temp. | Desiccate at -20°C | | solubility | Soluble to 1 mg/ml in 5% acetonitrile / sterile water | | form | Powder | | pka | 3.60±0.10(Predicted) | | color | White to off-white | | Sequence | Ala-Cys-Phe-Trp-Lys-Tyr-Cys-Val (Disulfide bridge:Cys2-Cys7) |
| | UROTENSIN II-RELATED PEPTIDE (HUMAN, MOUSE, RAT) Usage And Synthesis |
| Description | Potent endogenous agonist for the urotensin-II (UT) receptor. Binds with high affinity and potently activates recombinant rat and human UT receptors (EC50 values are 0.55 and 4.8 nM respectively). Produces hypotensive effects following systemic administration in rats. | | Uses | Urotensin II-related peptide is a human urotensin II anague. Urotensin II-related peptide has high affinity for the UT receptor[1][2]. | | References | [1] Lescot E, et al. Nonpeptide Urotensin-II receptor agonists and antagonists: Review and structure–activity relationships Peptides. 2008 May;29(5):680-90. DOI:10.1016/j.peptides.2007.09.019
[2] Labarrère P, et al. Structure-activity relationships of human urotensin II and related analogues on rat aortic ring contraction. J Enzyme Inhib Med Chem. 2003 Apr;18(2):77-88. DOI:10.1080/1475636031000093507 |
| | UROTENSIN II-RELATED PEPTIDE (HUMAN, MOUSE, RAT) Preparation Products And Raw materials |
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