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SB 269970 hydrochloride

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SB 269970 hydrochloride manufacturers

  • SB-269970
  • SB-269970 pictures
  • $3500.00
  • 2026-05-22
  • CAS:201038-74-6
  • Purity:
  • Supply Ability: 10g
  • SB-269970
  • SB-269970 pictures
  • $3500.00
  • 2026-05-21
  • CAS:201038-74-6
  • Purity:
  • Supply Ability: 10g
  • SB-269970
  • SB-269970 pictures
  • $4600.00
  • 2025-08-22
  • CAS:201038-74-6
  • Purity:
  • Supply Ability: 10g
SB 269970 hydrochloride Basic information
Product Name:SB 269970 hydrochloride
Synonyms:CS-776;SB-269970;SB 269970;SB269970HCl;(2R)-1-[(3-HYDROXYPHENYL)SULFONYL]-2-[2-(4-METHYL-1-PIPERIDINYL)ETHYL]PYRROLIDINE HYDROCHLORIDE;Pyrrolidine, 1-((3-hydroxyphenyl)sulfonyl)-2-(2-(4-methyl-1-piperidinyl)ethyl)-, (R)-;(R)-1-[(3-Hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl]pyrrolidine;(R)-3-((2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidin-1-yl)sulfonyl)phenol;Phenol, 3-[[(2R)-2-[2-(4-methyl-1-piperidinyl)ethyl]-1-pyrrolidinyl]sulfonyl]-
CAS:201038-74-6
MF:C18H28N2O3S
MW:352.49
EINECS:
Product Categories:Serotonin receptor
Mol File:201038-74-6.mol
SB 269970 hydrochloride Structure
SB 269970 hydrochloride Chemical Properties
Boiling point 512.9±56.0 °C(Predicted)
density 1.188
storage temp. Inert atmosphere,2-8°C
solubility H2O: 22 mg/mL
form solid
pka8.88±0.10(Predicted)
color White to off-white
Safety Information
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
SB 269970 hydrochloride Usage And Synthesis
UsesSB 269970 is a selective and potent SR-7 antagonist.
DefinitionChEBI: 3-[[(2R)-2-[2-(4-methyl-1-piperidinyl)ethyl]-1-pyrrolidinyl]sulfonyl]phenol is a sulfonamide.
Biological ActivityPotent and selective 5-HT 7 receptor antagonist (pK i values are 8.9, 7.2 and 6.0 for 5-HT 7A , 5-HT 5A and 5-HT 1B and < 6.0 for 5-HT 1A , 5-HT 1D , 5-HT 1E , 5-HT 1F , 5-HT 2A , 5-HT 2B , 5-HT 2C , 5-HT 4 and 5-HT 6 receptors respectively). Brain penetrant in vivo .
in vivo

SB-269970 (3-30 mg/kg; i.p.; once) significantly blocks amphetamine and ketamine-induced hyperactivity[2].

Animal Model:Male C57BL6/J mice[2]
Dosage:3, 10, 30 mg/kg
Administration:Intraperitoneal injection; once
Result:Significantly blocked amphetamine and ketamine-induced hyperactivity.
IC 50Human 5-HT7 Receptor: 8.3 (pKi)
SB 269970 hydrochloride Preparation Products And Raw materials
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