Mizagliflozin
| 中文名称 | Mizagliflozin |
|---|---|
| 中文同义词 | 化合物MIZAGLIFLOZIN;3 - ((3-(4 - ((5-异丙基-3 - (((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃 2-基)氧基)-1H-吡唑-4-基)甲基)-3-甲基苯氧基)丙基)氨基)-2,2-二甲基丙酰胺;DSP-3235;化合物MIZAGLIFLOZIN,10 MM DMSO 溶液;Mizagliflozin (KWA 0711) 试剂;Mizagliflozin (KWA 0711) 试剂;米扎利福津(KWA 0711) |
| 英文名称 | Mizagliflozin |
| 英文同义词 | Mizagliflozin;DSP-3235 free base;GSK-1614235 free base;KGA-3235 free base;Propanamide, 3-[[3-[4-[[3-(β-D-glucopyranosyloxy)-5-(1-methylethyl)-1H-pyrazol-4-yl]methyl]-3-methylphenoxy]propyl]amino]-2,2-dimethyl-;GSK1614235,Chronic,KGA 3235,DSP-3235,selective,Sodium-dependent glucose cotransporters,KGA-3235,constipation,Mizagliflozin,antidiabetic,disorder,SGLT,gastrointestinal,DSP 3235,inhibit,GSK 1614235,Inhibitor,KGA3235,GSK-1614235,DSP3235;Mizagliflozin (KWA 0711);GSK 1614235 |
| CAS号 | 666843-10-3 |
| 分子式 | C28H44N4O8 |
| 分子量 | 564.68 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 666843-10-3.mol |
| 结构式 |  |
Mizagliflozin 性质
| 沸点 | 837.0±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.274±0.06 g/cm3(Predicted) |
| 储存条件 | 4°C, protect from light |
| 溶解度 | 甲醇：250 mg/mL (442.74 mM)；二甲基亚砜：100 mg/mL（177.09 mM） |
| 形态 | 固体 |
| 酸度系数(pKa) | 12.65±0.70(Predicted) |
| 颜色 | 米白色至浅黄色 |
Mizagliflozin (KWA 0711)是一种新型、有效、选择性的 sodium glucose co-transporter 1 (SGLT1) 抑制剂，对human SGLT1的Ki值为27 nM。Mizagliflozin的选择性比(Ki value for human SGLT2/Ki value for human SGLT1)为303。Mizagliflozin还有改善慢性便秘的潜在应用。
| Target | Value |
|
human SGLT1
(Cell-free assay) | 27 nM(Ki) |
Mizagliflozin (DSP-3235 free base) (3-30 mg/kg; oral) exerts a laxative effect.
Mizagliflozin administrated intravenously (0.3 mg/kg) and orally (3 mg/kg) declined with a short half-life (0.23 and 1.14 h, respectively)
| Animal Model: | Male Wistar rats (rat model of low-fiber-diet-induced constipation) |
| Dosage: | 3, 10, 30 mg/kg |
| Administration: | Oral |
| Result: | Increased fecal wet weight in a rat model of low-fiber-diet-induced constipation. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/07/06 | S8939 | Mizagliflozin Mizagliflozin | 666843-10-3 | 5mg | 2170元 |
| 2026/07/06 | S8939 | Mizagliflozin (KWA 0711) | 666843-10-3 | 10mM (1mL in DMSO) | 2612.61元 |