| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
GSK466317A manufacturers
- GSK466317A
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- $1980.00
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2026-04-21
- CAS:864082-48-4
- Purity:
- Supply Ability: 10g
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| | GSK466317A Basic information |
| Product Name: | GSK466317A | | Synonyms: | GSK466317A;3-Pyridinecarboxamide, N-(7-chloro-1H-indazol-5-yl)-1,4,5,6-tetrahydro-2-methyl-6-oxo-4-[4-(trifluoromethyl)phenyl]- | | CAS: | 864082-48-4 | | MF: | C21H16ClF3N4O2 | | MW: | 448.83 | | EINECS: | | | Product Categories: | | | Mol File: | 864082-48-4.mol |  |
| | GSK466317A Chemical Properties |
| Boiling point | 713.4±60.0 °C(Predicted) | | density | 1.485±0.06 g/cm3(Predicted) | | pka | 11.54±0.40(Predicted) |
| | GSK466317A Usage And Synthesis |
| Description | GSK466317A is a GRK2 inhibitor. GRK2 has been directly implicated in the progression of heart failure. Selective inhibitors of individual subfamilies of G protein-coupled receptor kinases (GRKs) would serve as useful chemical probes as well as leads for therapeutic applications ranging from heart failure to Parkinson's disease. | | Uses | GSK466317A is a PKA inhibitor, with an IC50 of 12.59 μM. GSK466317A also inhibits GRK1, GRK2, and GRK5, with IC50s of 1000, 31.62, and 39.81 μM, respectively[1]. | | IC 50 | PKA: 12.59 μM (IC50) | | References | [1] Homan KT, et, al. Identification and structure-function analysis of subfamily selective G protein-coupled receptor kinase inhibitors. ACS Chem Biol. 2015 Jan 16;10(1):310-9. DOI:10.1021/cb5006323 |
| | GSK466317A Preparation Products And Raw materials |
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