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| | 6-Oxo-1,6-dihydro-pyridazine-3-carboxylicacid Basic information |
| Product Name: | 6-Oxo-1,6-dihydro-pyridazine-3-carboxylicacid | | Synonyms: | 6-Hydroxy-3-pyridazinecarboxylic acid monohydrate;6-Hydroxy-3-pyridazinecarboxylic acid;2,3-DIHYDRO-3-OXOPYRIDAZIN-6-CARBOXYLIC ACID, MONOHYDRATE;3-hydroxypyridazine-6-car...;6-oxo-1,6-dihydropyridazine-3-carboxylic acid(SALTDATA: FREE);6-oxo-1H-pyridazine-3-carboxylic acid;6-keto-1H-pyridazine-3-carboxylic acid;6-hydroxy-pyridazine-3-carboxylic acid | | CAS: | 37972-69-3 | | MF: | C5H4N2O3 | | MW: | 140.1 | | EINECS: | 675-237-1 | | Product Categories: | pyridazine;Pyridazine series | | Mol File: | 37972-69-3.mol |  |
| | 6-Oxo-1,6-dihydro-pyridazine-3-carboxylicacid Chemical Properties |
| Melting point | 246 °C | | density | 1.63±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | -2.86±0.20(Predicted) | | Appearance | White to yellow Solid |
| HazardClass | IRRITANT | | HS Code | 2933998090 |
| | 6-Oxo-1,6-dihydro-pyridazine-3-carboxylicacid Usage And Synthesis |
| Uses | 6-Hydroxypyridazine-3-carboxylic acid is a carboxylic acid derivative and can be used as an intermediate in organic synthesis. | | Synthesis | The general procedure for the synthesis of 6-hydroxypyridazine-3-carboxylic acid from 6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxylic acid was as follows: to a solution of 6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxylic acid (2.50 g, 17.59 mmol) in toluene (44 mL) was added sequentially copper acetate (450 mg, 2.48 mmol), sodium carbonate ( 7.01 g, 66.14 mmol) and pyridine (4.4 mL). The reaction mixture was stirred and mixed at room temperature, then warmed to 100 °C and stirred continuously for 16 hours. After completion of the reaction, the insoluble solid was removed by filtration and the filtrate was concentrated under reduced pressure to afford 6-oxo-1,6-dihydropyridazine-3-carboxylic acid as an off-white solid (1.80 g, 73% yield). Mass spectrometry result: m/z = 177.0 [M + H]+. | | References | [1] European Journal of Organic Chemistry, 2013, # 27, p. 6130 - 6136
[2] Patent: US2016/376283, 2016, A1. Location in patent: Paragraph 1225; 1226
[3] Patent: CN106187910, 2016, A. Location in patent: Paragraph 0120; 0121
[4] European Journal of Medicinal Chemistry, 2017, vol. 137, p. 598 - 611 |
| | 6-Oxo-1,6-dihydro-pyridazine-3-carboxylicacid Preparation Products And Raw materials |
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