LH1307 manufacturers
- LH1307
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- $1430.00
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2026-05-11
- CAS:2375720-38-8
- Purity:
- Supply Ability: 10g
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| Product Name: | LH1307 | | Synonyms: | LH1307;N,N'-(((((((2,2'-dimethyl-[1,1'-biphenyl]-3,3'-diyl)bis(methylene))bis(oxy))bis(2-((5-cyanopyridin-3-yl)methoxy)-5-methyl-4,1-phenylene))bis(methylene))bis(azanediyl))bis(ethane-2,1-diyl))diacetamide | | CAS: | 2375720-38-8 | | MF: | C54H58N8O6 | | MW: | 915.09 | | EINECS: | | | Product Categories: | | | Mol File: | 2375720-38-8.mol |  |
| | LH1307 Chemical Properties |
| Boiling point | 1072.4±65.0 °C(Predicted) | | density | 1.27±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF:25.0(Max Conc. mg/mL);27.32(Max Conc. mM)
DMSO:25.0(Max Conc. mg/mL);27.32(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.33(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);10.93(Max Conc. mM) | | form | A crystalline solid | | pka | 15.82±0.46(Predicted) | | color | white to beige | | InChIKey | RNCINFJGGSQEHN-UHFFFAOYSA-N | | SMILES | N#CC1=CC(COC2=C(C=C(C(OCC3=C(C(C4=CC=CC(COC5=CC(OCC6=CN=CC(C#N)=C6)=C(C=C5C)CNCCNC(C)=O)=C4C)=CC=C3)C)=C2)C)CNCCNC(C)=O)=CN=C1 |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | LH1307 Usage And Synthesis |
| Description | LH1307 is an inhibitor of the interaction between programmed cell death 1 (PD-1) and its ligand PD-L1. | | Uses | LH1307 is a C2-symmetric inhibitor of PD-1/PD-L1 protein-protein interactions with a IC50 value of 3.0 μM and can be used in cancer studies[1]. | | in vitro | C2-symmetric inhibitors 2a (LH1306) and 2b (LH1307) exhibited IC50 values of 25 and 3.0 nM, respectively, in the HTRF assay. In one cell-based coculture PD-1 signaling assay, 2a and 2b were 8.2- and 2.8-fold more potent in inhibiting PD-1 signaling than 1a and 1b, respectively._x000D_
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Reference: J Med Chem. 2019 Aug 8;62(15):7250-7263. https://pubmed.ncbi.nlm.nih.gov/31298541/ | | target | LH1307 is an inhibitor of the interaction between programmed cell death 1 (PD-1) and its ligand PD-L1. | | References | [1] Basu S, et al. Design, Synthesis, Evaluation, and Structural Studies of C2-Symmetric Small Molecule Inhibitors of Programmed Cell Death-1/Programmed Death-Ligand 1 Protein-Protein Interaction. J Med Chem. 2019 Aug 8;62(15):7250-7263. DOI:10.1021/acs.jmedchem.9b00795 |
| | LH1307 Preparation Products And Raw materials |
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